Beta
ManageSearchChatDiscover
390809

Granzyme-B gene Polymorphisms and Susceptibility of Breast Cancer Patients in Egypt

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Background: Breast cancer (BC) is the most common type of female cancer in Egypt. Granzyme B (GrB) is primarily found in cytotoxic granules and has been considered the most abundant Granzyme. However, recent research has revealed various other crucial roles for GrB. Objectives: In this study, we aimed to examine Granzyme-B (GrB) expression as well as to investigate whether a common genetic variation in the gene encoding GrB, among two single nucleotide polymorphisms (rs8192917, rs2236338), is associated with breast cancer risk in Egyptian women. Methodology: This study included 195 participants, with 103 cases diagnosed with breast cancer and 92 serving as controls. Flow cytometry was used to assess anti-Granzyme B expression, while genotyping of the Granzyme B gene variants (rs8192917, rs2236338) was conducted. Results: We observed a substantial decrease (p < 0.001) in the percentage of Granzyme B in breast cancer patients compared to healthy women, with an odds ratio of 10.110 (95% confidence interval: 4.966-20.582). In rs8192917, The GG genotype and G allele could be considered risk factors for breast cancer (OR= 1.22, 95% CI: 1.02-1.22, P<0.001) and G allele (OR = 5, 95% CI:  2- 12.53, P=00).  Additionally, in rs2236338, GC and GG genotypes , and the C allele was; OR =3.91  (95%  CI:  1.07-14.3, OR = 0.233 (95% CI:  0.069-0.86),   and  4.09  (95%  CI:  1.15-14.57), respectively  could  all  be  risk  factors  for breast cancer. Conclusion: The variant allele (rs8192917 and Granzyme-B (GrB) expression) could be considered as a predictive factor for breast cancer development in Egyptian females.

DOI

10.21608/ejmm.2024.331040.1362

Keywords

breast cancer, SNP polymorphism, Granzyme B (GrB), Egyptian patients, case-control study

Authors

First Name

Fatma

Last Name

Osman

MiddleName

E.E.

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

dr_basma_111@hotmail.com

City

-

Orcid

-

First Name

Sobhy

Last Name

El Nabi

MiddleName

H.

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

drsobhyhassabelnabi@science.menofia.edu.eg

City

-

Orcid

-

First Name

Islam

Last Name

El-Garawani

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

dr.garawani@science.menofia.edu.eg

City

menofia

Orcid

-

First Name

Ehab

Last Name

Oraby

MiddleName

M.

Affiliation

General Surgery, Faculty of Medicine, Benha University, Egypt

Email

ehab.arabi@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Mahmoud

Last Name

Kamel

MiddleName

M.

Affiliation

Clinical Pathology, National cancer institute, Cairo University, Egypt

Email

mahmoud.kamel@nci.cu.edu.eg

City

-

Orcid

-

First Name

Heba

Last Name

Hathout

MiddleName

M.R.

Affiliation

Natural resources department, Faculty of African Postgraduate Studies, Cairo University, Egypt

Email

hathoutheba@cu.edu.eg

City

Shebin el kom

Orcid

-

First Name

Mona

Last Name

Abo El-Ela

MiddleName

M.

Affiliation

General Surgery, Faculty of Medicine, Benha University, Egypt

Email

abuelela.mona@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-10-25

Publish Date

2025-01-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_390809.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=390809

Order

390,809

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Granzyme-B gene Polymorphisms and Susceptibility of Breast Cancer Patients in Egypt

Details

Type

Article

Created At

28 Dec 2024