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390325

Hepatitis Virus-related microRNA-122 gene and Biochemical Parameters in Iraqi Patients with Hepatocellular Carcinoma

Article

Last updated: 07 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Chronic HBV and HCV infections may modify hepatocyte function via comparable pathways that impact the development of hepatocellular carcinoma. Our understanding of the molecular biology of HBV and HCV, as well as the cellular signal transduction pathways affected by these illnesses, has advanced significantly. Several cancer types have aberrant expression and deregulation of microRNA-122, which raises the possibility that these molecules may function as prognostic and diagnostic biomarkers. In a global context, noninvasive biomarkers have limited application for the detection of HCC. Early identification is vital to enhance the survival percentage of individuals with HCC. Methodology: Clinical diagnosis of HCC was made, and laboratory work was done. Patients were divided into two groups: those getting therapy and those not. After that, a blood sample was taken from 24 individuals of various ages and genders. A handful of them had just been diagnosed with HCC. Results: This study was significance of HCV and HB V and liver cancer, as well as the decline in research and studies in Iraq. The microRNA-122 expression levels were marginally increased in individuals who received therapy and decreased in those who were diagnosed early and did not receive any therapy. In the first phase of hepatitis samples, the microRNA-122 expression levels were considerably lower than in standard samples, with (P < 0.0001), suggesting the possible use of microRNA-122 as a biomarker to track treatment success. It is suggested that further study should be done in this field to aid diagnosis.    Conclusion: MicroRNAs have a high degree of specificity and dependability, making them an invaluable tool for tracking illness development and recurrence as well as for early diagnosis. Additionally, these indicators may function as a predictor of HCC advancement in individuals with a history of hepatitis B or C. Our findings show that, in comparison to healthy controls, HCC patients with HBV and HCV had lower expression         levels of miR-122. Untreated HCC patients had considerably decreased expression of miR-122 compared to treated HCC patients and healthy controls.

DOI

10.21608/ejmm.2024.317083.1324

Keywords

microRNA-122, Hepatocellular carcinoma, hepatitis B, hepatitis C

Authors

First Name

Rana

Last Name

Mohsen

MiddleName

T.

Affiliation

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar

Email

ranatalib33@yahoo.com

City

-

Orcid

-

First Name

Iman

Last Name

Khudhair

MiddleName

A.

Affiliation

Department of Biology, College of Science, University of Anbar, Al-Anbar

Email

imanbbashudh@yahoo.com

City

-

Orcid

-

First Name

Mithal

Last Name

Alkubaisi

MiddleName

R.

Affiliation

Department of Biochemistry, College of Medicine, University of Anbar, Al-Anbar

Email

mithallkubaisi22@yahoo.com

City

-

Orcid

-

First Name

Al-Taee

Last Name

Haneen Z.

MiddleName

-

Affiliation

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar

Email

aeeaneen22@yahoo.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Habeeb

MiddleName

H.

Affiliation

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar

Email

wafaahussain1@gmail.com

City

-

Orcid

-

First Name

Sally

Last Name

Hassan

MiddleName

-

Affiliation

Department of Biology, College of Science, University of Anbar, Al-Anbar

Email

sallyhassan66@yahoo.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-10-01

Publish Date

2025-01-01

Page Start

141

Page End

148

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 1_Pages 141-148.pdf

PDF . 421.9kB

Link

https://ejmm.journals.ekb.eg/article_390325.html

Detail API

http://journals.ekb.eg?_action=service&article_code=390325

Order

16

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Hepatitis Virus-related microRNA-122 gene and Biochemical Parameters in Iraqi Patients with Hepatocellular Carcinoma

Details

Type

Article

Created At

28 Dec 2024