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388759

IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Host response

Abstract

Background: The inflammatory role of some cytokines in allergic rhinitis (AR) is not yet well illustrated. Understanding its role may form a target for novel therapeutics. Objectives: To assess the levels of IL-17, TNF-α, IL-8 and IL-22 in sera of AR patients and to correlate their levels with disease severity. Methodology: This case-control study included 26 AR patients and 26 healthy controls. Blood samples of all participants were tested for levels of total IgE, IL-17, TNF-α, IL-8 and IL-22 serum using ELISA method. Skin prick test (SPT) and Specific IgE (sIgE) for aeroallergens were done by immunoblot assay for all AR patients.  Results: AR patients possessed higher serum levels of IL-17, IL22, TNF-α and IL-8 (P= 0.006, <0.00, 0.013 and<0.001 respectively) compared to the control group. There was a statistically significant relation between disease severity (evaluated through visual analogue score (VAS)) and TNF-α& IL-22 serum levels (P= 0.031& <0.001 respectively). Conclusion: IL-17, IL-22, TNF-α and IL-8 promote the inflammatory response in AR patients. TNF-α and IL-22 were directly correlated with AR severity.

DOI

10.21608/ejmm.2024.326786.1354

Keywords

allergy, Allergen, interleukin, cytokine, chemokine

Authors

First Name

Yasmin

Last Name

Fahmy

MiddleName

A.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

yasminfahmy@yahoo.com

City

Zagazig

Orcid

-

First Name

Lobna

Last Name

El-Korashi

MiddleName

A.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

alqurashilobna@yahoo.com

City

Zagazig

Orcid

-

First Name

Haitham

Last Name

Attia

MiddleName

M.

Affiliation

ENT Specialist, Al-Ahrar Teaching Hospital, Zagazig, Egypt

Email

haithammmattia@gmail.com

City

Zagazig

Orcid

-

First Name

Osama

Last Name

Attia

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

ommattia2@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

Behiry

MiddleName

S.

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

ahmedbihery@hotmail.com

City

Zagazig

Orcid

-

First Name

Hend

Last Name

El-sayed

MiddleName

A.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dr_heam85@yahoo.com

City

Zagazig

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-10-08

Publish Date

2025-01-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_388759.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=388759

Order

388,759

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

IL-22, TNF-α, IL-17, and IL-8 in Allergic Rhinitis and Correlation with Disease Severity

Details

Type

Article

Created At

28 Dec 2024