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387402

Correlation of Cytokines with Thyroid Hormones and Autoantibodies in Thyroid Autoimmune Diseases

Article

Last updated: 28 Dec 2024

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-

Tags

Clinical microbiology

Abstract

Background: The autoimmune thyroid diseases (AITDs), like hyperthyroidism Graves' Disease (GD) and hypothyroidism Hashimoto's Thyroiditis (HT), are common occurrence autoimmune disease associated with thyroid hormones and immunity (autoantibodies and cytokine like IL-27 and IL-1β) disturbance. Objective: The aim of current study is to study and determine the relation of IL-27 and IL-1β cytokines with thyroid hormones and autoantibodies. Methodology: 150 participants in total (50 GD, 50 HT, and 50 control) all between the ages of 20 and 60 were attending Al-Sader Teaching Hospital in Al-Najaf. The ELISA kits were used to measure levels of IL27 and IL1β (MyBioSource, USA), and levels of thyroid hormones fT3, fT4, TSH (Elabscience firm, USA), whereas autoantibodies (TR Ab, TPO Ab, and Tg Ab) were measured by Cobas e411 instrument. Results: the patients were insignificantly more female; significantly older; and significantly had family history, body mass index, abnormal weight, urban residence than control. However, significantly (P=0.001) the levels of fT3 fT4 were high in GD and low in HT, and vice versa in TSH. The immunity including autoantibodies (TR Ab, TPO Ab, and Tg Ab) and Cytokine (IL27 and IL1β) were significantly (P=0.001) dysregulated and have increased level in GA and HT than control. The are positive correlation of IL27 and negative correlation of IL-1β with most parameters. Conclusion: AITDs resulted from immunity dysfunction and underlined by correlation of cytokine IL-27 and IL-1β with thyroid hormone and autoantibodies, however, TSH had positive correlation with IL-27 in HT and negative correlation with IL-1β in GD.

DOI

10.21608/ejmm.2024.322552.1344

Keywords

Graves' disease, Hashimoto's thyroiditis, IL-27, IL-1β, Autoantibodies

Authors

First Name

Ali Razzaq

Last Name

Hussein

MiddleName

R.

Affiliation

Directorate of Education in Al-Najaf, Ministry of Education, Al-Najaf, Iraq

Email

fatimakarimnasser@gmail.com

City

-

Orcid

-

First Name

Khamael

Last Name

Al-challabi

MiddleName

A.M

Affiliation

Al-Furat Al-Awsat University, Al-Najaf, Iraq

Email

khamael.alchallabi@atu.edu.iq

City

-

Orcid

-

First Name

Wurood

Last Name

Abed

MiddleName

K.

Affiliation

Faculty of Medical Science, Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Al-Najaf, Iraq

Email

worood.k.abd@jmu.edu.iq

City

-

Orcid

-

First Name

Haider

Last Name

Mahdi

MiddleName

A.

Affiliation

Al-Najaf Health Directorate, Iraqi Ministry of Health, Al-Najaf, Iraq

Email

heider21555@gmail.com

City

-

Orcid

-

First Name

Anwer

Last Name

Al-Hatimy

MiddleName

N.

Affiliation

Al-Najaf Health Directorate, Iraqi Ministry of Health, Al-Najaf, Iraq

Email

anwarnajh@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-09-20

Publish Date

2025-01-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_387402.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=387402

Order

387,402

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Correlation of Cytokines with Thyroid Hormones and Autoantibodies in Thyroid Autoimmune Diseases

Details

Type

Article

Created At

28 Dec 2024