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385499

Diagnostic Utility of Peptidoglycan Recognition Protein 2 (PGLYRP2) in Systemic Lupus Erythematosus Patients Attending Benha University Hospitals

Article

Last updated: 07 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: PGLYRP2 is essential for innate immune responses and contributes to the progression of chronic inflammation. Elevated PGLYRP2 levels can result in prolonged inflammation. So in individuals with SLE, the concentration of PGLYRP2 in the blood rises significantly and is linked to a higher SLEDAI score. Objectives: This work was conducted to assess the PGLYRP2 level in the SLE patient's serum and study its association with clinical manifestations, laboratory parameters, disease activity and organ damage. Methodology: twenty-five SLE patients' blood samples were obtained, leucocytes were isolated and PGLYRP2 expression was evaluated by RT-PCR then serum PGLYRP2 levels were detected by ELISA. Twenty-five healthy participants, selected to match in age and gender, were designated as the control group. Results: PGLYRP2 expression level in the leucocytes was higher in the SLE group than in the healthy control group (p< 0.05). The gene expression in the cases group was relatively higher. Serum PGLYRP2 levels were significantly higher in cases with SLE with range between (1.34-5.73) ng /mL (p< 0.05). Conclusion: Our results support the hypothesis that PGLYRP2 contributes in the development of the pathogenesis of SLE, activity of disease. PGLYRP2 appears to serve as a useful marker with good sensitivity.

DOI

10.21608/ejmm.2024.325094.1348

Keywords

PGLYRP2, Systemic lupus erythematosus, RT-PCR, ELISA

Authors

First Name

Emad

Last Name

Basiouny

MiddleName

A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Egypt

Email

emadbasiony50@gmail.com

City

-

Orcid

-

First Name

Said

Last Name

Abbadi

MiddleName

H.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez University, Egypt

Email

saidabbadi@hotmail.com

City

-

Orcid

-

First Name

Rasha

Last Name

Fawzy

MiddleName

M.

Affiliation

Department of Rheumatology, Rehabilitation and Physical medicine, faculty of Medicine, Benha University, Egypt

Email

dr.rasha.fawzy@hotmail.com

City

-

Orcid

-

First Name

Sarah

Last Name

Egila

MiddleName

S.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez University, Egypt

Email

sarahsamyto@gmail.com

City

Mansoura

Orcid

-

First Name

AL-Shaimaa

Last Name

AL-Tabbakh

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Egypt

Email

alshaimaaaltabbakh@gmai.com

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-10-02

Publish Date

2025-01-01

Page Start

81

Page End

89

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 1_Pages 81-89.pdf

PDF . 458.8kB

Link

https://ejmm.journals.ekb.eg/article_385499.html

Detail API

http://journals.ekb.eg?_action=service&article_code=385499

Order

10

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Diagnostic Utility of Peptidoglycan Recognition Protein 2 (PGLYRP2) in Systemic Lupus Erythematosus Patients Attending Benha University Hospitals

Details

Type

Article

Created At

28 Dec 2024