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383285

Detection of toxoplasma gondii among Autoimmune Thyroid Disease (AITD) and Estimation its Association with Transforming Growth Factor-β (TGF-β)

Article

Last updated: 28 Dec 2024

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Toxoplasmosis is the most common parasitic infection in the world, caused by T. gondii that is associated with a number of problems such as thyroid diseases, the most prevalent endocrine disorders secondary to diabetes. Objectives: This study aims to investigate the relationship between latent toxoplasmosis and autoimmune thyroid diseases and estimation its association with the transforming growth factor. Methodology The study included 100 patients with AITD and 70  normal control who entered Thi-Qar Specialized Diabetes, Endocrine Center in Nasiriyah city, Southern Iraq. The samples were collected during a period from August to November (2023) using ElectrochemiLuminescence and ELISA methods to determine the presence AITD and  anti T.gondii (IgG) . Results: This study showed 33% of patients with AITD infected with T. gondii and the age of them ranged between15-70 years, Additionally the current study showed an association between sex of patients with AITD infected T.gondii . Also, in the present study the level of TGF among Graves' patient infected with T.gondii was (170 ±  22.8 pg/ml)  compared with Graves' patient without T.gondii, it was (171 ± 18.6) while in the control group it was (213.3 ± 31.6,177  ±  22.4) respectively, TGF.β level in patients with Hashimotos thyroiditis infected with T.gondii was (145.66 ± 18.6  ) compared with Hashimotos thyroiditis without T.gondii  (133.11±  28.8) while the control group was (213.3 ± 31.6,177  ±  22.4) respectively. Conclusion: The molecular mimicry hypothesis suggests a resemblance between human thyroid autoantigens and molecular components of T.gondii; the generation specific autoantibodies against thyroid.

DOI

10.21608/ejmm.2024.319415.1336

Keywords

Toxoplasmosis, Autoimmune Thyroid Disease, ELISA, transforming growth factor β

Authors

First Name

Akram

Last Name

Haddad

MiddleName

H.

Affiliation

Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 6400

Email

akram-h22@utq.edu.iq

City

-

Orcid

-

First Name

Amal

Last Name

Khalaf

MiddleName

K.

Affiliation

Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 6400

Email

aml-kh@utq.edu.iq

City

nassiryha

Orcid

-

First Name

Dheyaa

Last Name

Al-Waeli

MiddleName

K.

Affiliation

Department of internal medicine, College of Medicine, University of Thi-Qar, Thi- Qar, 64001

Email

dheya.k@utq.edu.iq

City

Nassiryha

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-09-09

Publish Date

2025-01-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_383285.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=383285

Order

383,285

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Detection of toxoplasma gondii among Autoimmune Thyroid Disease (AITD) and Estimation its Association with Transforming Growth Factor-β (TGF-β)

Details

Type

Article

Created At

28 Dec 2024