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378539

The Efficacy of Sublingual Immunotherapy with Traditional Coca’s Extract as a Treatment of Respiratory Allergy

Article

Last updated: 07 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Allergic manifestations affect adults and children worldwide and the symptoms interfere with daily activities of the patients. Objective: To evaluate the efficacy of Sublingual (SLIT) versus Subcutaneous (SCIT) Immunotherapies in treating respiratory allergy, and to compare the SLIT protocol applied in Egypt with that applied in France. Methodology: This study included 83 allergic patients (Egyptian and French). The diagnosis of respiratory allergy was performed clinically and laboratory. All Egyptian patients were subjected to skin prick test using different homemade Coca's extracted allergens. Total and specific serum IgE levels were detected by enzyme linked immunosorbent assay before and after 6 months of immunotherapy. Patients were divided into three groups: Group I included 28 Egyptian patients receiving SLIT, Group II included 30 Egyptian patients receiving SCIT and Group III included 25 French patients receiving SLIT. Results: After 6 months of immunotherapy, there was a significant decrease in total and specific IgE levels in Group I patients (P <0.05). In group II, specific IgE levels were significantly decreased (p> 0.05), except for wool, cotton and Aspergillus fungi. Analysis of the symptoms of Egyptian patients before and after 6 months of treatment revealed that all symptoms were significantly improved in both groups (P <0.05), but SLIT was significantly superior to SCIT in improving nasal obstruction and discharge (P<0.05). Comparing protocols used in Egypt versus France, we found the disappearance of allergic symptoms in some patients; a significant decrease in the number of group II cases (P <0.001) was detected. No change in symptoms in French patients was detected. Conclusion: SLIT with Coca's extracted allergen showed good efficacy in the treatment of respiratory allergy.

DOI

10.21608/ejmm.2024.312676.1306

Keywords

Allergic Rhinitis, allergic conjunctivitis, Allergic asthma, Immunotherapy, Coca’s extracted allergen

Authors

First Name

Rasha

Last Name

Bassyouni

MiddleName

H.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

rhb00@fayoum.edu.eg

City

Giza

Orcid

0000-0003-2468-4948

First Name

Fatma

Last Name

Eldally

MiddleName

O.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, October 6 University, Cairo, Egypt; Department of Medical Microbiology and Immunology, Faculty of Medicine, King Salman International University, South Sinai, Egypt

Email

dr.fatmaeldally@hotmail.com

City

-

Orcid

-

First Name

Boris

Last Name

Melloni

MiddleName

-

Affiliation

Pulmonary diseases Department, CHU, Limoges, France

Email

boris.melloni@unilim.fr

City

-

Orcid

-

First Name

François

Last Name

Touraine

MiddleName

-

Affiliation

Pulmonary diseases Department, CHU, Limoges, France

Email

-

City

-

Orcid

-

First Name

Achraf

Last Name

Elrakabawy

MiddleName

A.

Affiliation

Department of Ear, Nose and Throat, Faculty of Medicine, October 6 University, Cairo, Egypt

Email

achrafelrakabawy@gmail.com

City

-

Orcid

-

First Name

Amal

Last Name

Atta

MiddleName

H.

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

amalatta166@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Wegdan

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

ashrafwegdan@yahoo.com

City

Giza

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-08-19

Publish Date

2025-01-01

Page Start

19

Page End

29

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 1_Pages 19-29.pdf

PDF . 531.5kB

Link

https://ejmm.journals.ekb.eg/article_378539.html

Detail API

http://journals.ekb.eg?_action=service&article_code=378539

Order

3

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Efficacy of Sublingual Immunotherapy with Traditional Coca’s Extract as a Treatment of Respiratory Allergy

Details

Type

Article

Created At

28 Dec 2024