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The Positive Impact of Combined Treatment of Tazarotene and Systemic Antifungal on Onychomycosis

Article

Last updated: 07 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Onychomycosis is a nail plate fungal infection with low initial cure rates and high relapse. Current treatment choices consist of topical and oral therapies. Tazarotene is a synthetic retinoid, with anti-inflammatory activities. Objectives: to investigate the effect of topical Tazarotene with and without systemic antifungal as a treatment of onychomycosis. Methodology: This work is a prospective, comparative, observational study. Thirty onychomycosis patients (with nail changes) were recruited out of 300 patients admitted to the dermatology clinic at Fayoum University Hospital , they were divided into three groups, group I: 10 patients treated with topical Tazarotene,  group II: 10 patients treated with systemic antifungals, and  group III: 10 patients treated with both. The groups were evaluated clinically by onychomycosis severity index (OSI) and laboratory by direct film and fungal culture of nail samples taken by scraping or clipping before and after treatment of all patients. Results: Trichophyton mentagrophyte (20%), was the commonest isolated fungus followed by Epidermophytone floccosum and candida species (13.3% each).  After 3 months of treatment: (group I) showed improvement clinically with no lesion within 30% of patients (especially lesions of mild and moderate cases). Also (group II) showed improvement in cases cured with 50% of patients with no lesion. Group III showed 70% of patients (all cases especially severe cases) clinically no lesion. Conclusion: Combined treatment of Tazarotene and systemic antifungal has a worthy clinical effect on all onychomycosis especially severe cases also Tazarotene alone is a safe and effective cure choice for mild and moderate onychomycosis.

DOI

10.21608/ejmm.2024.313492.1311

Keywords

Onychomycosis, Tazarotene, systemic antifungal, Combined treatment

Authors

First Name

Amel

Last Name

Hassan

MiddleName

R.

Affiliation

Department of Dermatology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Email

arh11@fayoum.edu.eg

City

-

Orcid

-

First Name

Talal

Last Name

Abdel-Raheem

MiddleName

A.

Affiliation

Department of Dermatology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Email

taa02@fayoum.edu.eg

City

-

Orcid

-

First Name

Nahla

Last Name

Khalifa

MiddleName

S.

Affiliation

Department of Dermatology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Email

nahlakhalifa1991@gmail.com

City

Fayoum

Orcid

-

First Name

Rasha

Last Name

Bassyouni

MiddleName

H.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Email

rhb00@fayoum.edu.eg

City

Giza

Orcid

0000-0003-2468-4948

First Name

Sylvana

Last Name

Gaber

MiddleName

N.

Affiliation

Medical Microbiology and Immunology Fayoum University Faculty of Medicine

Email

sng00@fayoum.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

1

Related Issue

50252

Issue Date

2025-01-01

Receive Date

2024-08-21

Publish Date

2025-01-01

Page Start

11

Page End

18

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 1_Pages 11-18.pdf

PDF . 509.1kB

Link

https://ejmm.journals.ekb.eg/article_378537.html

Detail API

http://journals.ekb.eg?_action=service&article_code=378537

Order

2

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Positive Impact of Combined Treatment of Tazarotene and Systemic Antifungal on Onychomycosis

Details

Type

Article

Created At

28 Dec 2024