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379640

Association study of rs2243188 (interleukin-19) and rs933717 (MAP1LC3B) polymorphisms with Juvenile systemic lupus erythematosus and Juvenile lupus nephritis in Egyptian population

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

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-

Tags

Genetics

Abstract

Background: An autoimmune connective tissue illness that affects several organs and lowers a patient's quality of life is the juvenile systemic lupus erythematosus (JSLE) and associated juvenile lupus nephritis (JLN). Interleukin-19 (IL-19) has both anti- and pro- inflammatory actions. LC3-associated phagocytosis (LAP) regulates immune responses to dying cells. Polymorphisms disrupting both mechanisms have been correlated to autoimmune diseases. Objective: to determine whether single-nucleotide polymorphisms (SNPs) of rs2243188 (IL-19) and/or rs933717 (MAP1LC3B) exhibit meaningful relationship with JSLE and /or JLN in the Egyptian population. Methodology: forty-seven JSLE patients and fifty matched healthy controls (HC) were included. SNPs identification was done using allelic discrimination real-time polymerase chain reaction (PCR) technology. Results: Genotyping of rs933717 and rs2243188 showed no statistical difference between the two studied groups with (P=0.206 and 0.468 respectively). Similarly, there was no significant difference in allele frequencies in neither rs933717 nor rs2243188 (P= 0.362 and 0.552 respectively). Twenty-nine out of the 47 JSLE patients (61.7%) displayed JLN symptoms. Similarly, JLN revealed no significant difference in either the genotype distribution or the allele frequency in the dominant/negative model for both genes. Likewise, there was no significant difference in the frequency of any allele concerning rs933717 or rs2243188, (P= 0.309 and 0.196 respectively). Conclusion: Interleukin-19 rs2243188 and MAP1LC3B rs933717 polymorphisms do not seem to play any role in the pathogenesis of JSLE or JLN in Egyptian population.

DOI

10.21608/ejmm.2024.316603.1320

Keywords

IL-19 rs2243188, MAP1LC3B rs933717, Juvenile systemic lupus: SLE, Lupus nephritis

Authors

First Name

Ingy

Last Name

Ashmawy

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt

Email

ingyashmawy@ymail.com

City

Cairo, Egypt

Orcid

0000-0002-6598-3568

First Name

Abeer

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Molecular Genetics and Enzymology, Human Genetics and Genome Research Institute, National Research Centre, Cairo, Egypt

Email

dr_aramadan1978@yahoo.com

City

Cairo, Egypt

Orcid

-

First Name

Nora

Last Name

Elsaid

MiddleName

Y.

Affiliation

Rheumatology Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

norayousry@kasralainy.edu.eg

City

Cairo, Egypt

Orcid

0000-0002-6598-3568

First Name

Maha

Last Name

Abdelhadi

MiddleName

-

Affiliation

Internal Medicine Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt

Email

mahahadi39@yahoo.com

City

Cairo, Egypt

Orcid

-

First Name

Irene

Last Name

Bishai

MiddleName

-

Affiliation

Clinical and Chemical Pathology Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

irir@aucegypt.edu

City

Cairo, Egypt

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-08-29

Publish Date

2024-10-01

Page Start

203

Page End

209

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 203-209.pdf

PDF . 354.0kB

Link

https://ejmm.journals.ekb.eg/article_379640.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=379640

Order

25

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association study of rs2243188 (interleukin-19) and rs933717 (MAP1LC3B) polymorphisms with Juvenile systemic lupus erythematosus and Juvenile lupus nephritis in Egyptian population

Details

Type

Article

Created At

28 Dec 2024