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378797

Immune-related miRNAs (181a, 146, 150) Expression in Colostrum and Mature Maternal Milk in normally and Caesarean Delivered Females

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Background: Breast milk is rich in microRNAs that is important for human growth, development, and immune–mediated protection. The method of delivery could alter the wide range of compounds and bioactive molecules present in the human breast milk. Objectives: in this work we studied the expression of the immune-related miRNAs (miR-181a, miR-150, and miR-146) in colostrum and mature human milk in normally delivered and cesarean section delivered females to assess the delivery method impact on their expression levels. Methodology: a cross-section study included 32 females; 16 delivered by normal vaginal delivery and 16 by cesarean section. Colostrum and mature milk were obtained from each female and the expression level of miR-181a, miR-150, and miR-146 were assessed. Results: The expression of miR-181a and miR-146 were significantly higher in colostrum than mature breast milk among all participants (P 0.008, 0.020) and among normal vaginal delivery women (P 0.019, 0.045). While only miR-181a was significantly expressed in colostrum than mature breast milk of cesarean section delivered women (P 0.012). Conclusion: The immune-related miRNAs (miR-181a, miR-146 and miR-150) are variably expressed in colostrum and mature milk of mothers gave birth by different methods of delivery. Thus, feeding newborns with all breast milk stages is essential to help their immune system development and maturation and the mode of delivery affects the bioactive molecules profiles in human breast milk.

DOI

10.21608/ejmm.2024.315547.1317

Keywords

Colostrum, mature milk, miRNAs, vaginal delivery, cesarean section

Authors

First Name

Riham

Last Name

Ragab

MiddleName

N.

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

rnragab@yahoo.com

City

Benha

Orcid

-

First Name

Ola

Last Name

El-Shimi

MiddleName

S.

Affiliation

Clinical and Chemical Pathology department, Faculty of Medicine, Benha University, Benha, Egypt

Email

ola.samer@fmed.bu.edu.eg

City

-

Orcid

0000-0001-8276-8352

First Name

Rasha

Last Name

Zakaria

MiddleName

M.

Affiliation

Pediatrics and Neonatology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

rasha.radwan@fmed.bu.edu.eg

City

Benha

Orcid

-

First Name

Amira

Last Name

Khalil

MiddleName

E.

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

amira.emam2006@gmail.com

City

Benha

Orcid

-

First Name

Mai

Last Name

Anwer

MiddleName

M.

Affiliation

Public Health, Community, Environmental and Occupational Medicine Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

mai.saber@fmed.bu.edu.eg

City

Benha

Orcid

-

First Name

Shaymaa

Last Name

Abdelrahman

MiddleName

M.

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

shaimaa.bghdadi@fmed.bu.edu.eg

City

Benha

Orcid

-

First Name

Hebatallah

Last Name

Mohammed

MiddleName

E.

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

heba.emam@fmed.bu.edu.eg

City

Benha

Orcid

-

First Name

Heba-Allah

Last Name

EL-Marakby

MiddleName

F.

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

heba.elmarakby@gmail.com

City

Benha

Orcid

-

First Name

Doaa

Last Name

Shaker

MiddleName

A.

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Benha University, Benha, Egypt

Email

doaa.shaker@fmed.bu.edu.eg

City

Benha

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-08-26

Publish Date

2024-10-01

Page Start

187

Page End

193

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 187-193.pdf

PDF . 495.8kB

Link

https://ejmm.journals.ekb.eg/article_378797.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=378797

Order

23

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Immune-related miRNAs (181a, 146, 150) Expression in Colostrum and Mature Maternal Milk in normally and Caesarean Delivered Females

Details

Type

Article

Created At

28 Dec 2024