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376268

A study of the prevalence of PGR gene expression with ER and PR Receptor markers positivity in female breast cancer cases in Al-Najaf province, Iraq

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Breast cancer is the leading cause of mortality among women globally. Numerous predisposing risk factors have been identified, making their incidence constantly increasing. Progesterone and the receptors for it binds to have critical roles in mammary gland development and breast carcinogenesis, indicating. Progesterone and its associated signaling pathways are necessary factors in initiating, advancing, and maintaining the neoplastic phenotype of the mammary gland. PR status is an important biomarker for classifying breast cancer subtypes and predicting prognosis. Objectives: The current research aims to investigate the PGR expression in Iraqi females diagnosed with PR+ breast cancer. Methodology: A total of seventy tissue samples were collected, with 36 being malignant breast tissue, 19 benign fibroadenoma samples, and 15 being normal were examined using immunohistochemistry to select PR+ samples, and then using RT-qPCR to assess PGR gene expression. Results: The PR samples showed the highest percentage of positivity at 59.91% of all samples. The PGR gene expression was noted to be inconsistent in all patient samples, with no significant difference in Iraqi female BC patients compared to IHC positive results. Conclusions: PR status serves as a crucial biomarker in the categorization of different types of breast cancer, prognosis, prediction, and treatment decision-making.  No significant PGR gene expression was detected in Iraqi BC patients, with most patients exhibiting positive PR receptors with high scores which mean the testing for PGR is considered optional. PR positivity is generally associated with an improved prognosis and is predictive of a favorable reaction to hormones therapies.

DOI

10.21608/ejmm.2024.308623.1299

Keywords

Breast cancer (BC), prostate cancer (PC), progesterone receptors (PRs), (HER2, Er, PR, IHC)

Authors

First Name

Jinan

Last Name

Alfatlawi

MiddleName

H.

Affiliation

Faculty of Medicine, Basic Sciences Department, University of Kufa, Najaf, Iraq

Email

jinanhamzah@yahoo.com

City

najaf

Orcid

-

First Name

Mohammad

Last Name

Alzeyadi

MiddleName

J.

Affiliation

Faculty of Science, Biology Department, University of Kufa, Najaf, Iraq

Email

mohammadaber@yahoo.com

City

najaf

Orcid

-

First Name

Ali

Last Name

Abood

MiddleName

H.

Affiliation

Faculty of Science, Biology Department, University of Kufa, Najaf, Iraq

Email

alihassanood3@yahoo.com

City

najaf

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-08-12

Publish Date

2024-10-01

Page Start

135

Page End

142

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 135-142.pdf

PDF . 561.1kB

Link

https://ejmm.journals.ekb.eg/article_376268.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=376268

Order

18

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

A study of the prevalence of PGR gene expression with ER and PR Receptor markers positivity in female breast cancer cases in Al-Najaf province, Iraq

Details

Type

Article

Created At

28 Dec 2024