Beta
ManageSearchChatDiscover
375087

Role of Interleukin-17 in the Pathogenesis and Progression of Coronary Artery Disease

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Coronary artery disease (CAD) remains one of the leading causes of morbidity and mortality worldwide. Inflammation is a critical component of CAD pathogenesis, with interleukin-17 (IL-17) emerging as a key pro-inflammatory cytokine involved in various autoimmune and inflammatory diseases. Objective: This study investigates the role of IL-17 in CAD, examining its potential as a biomarker for disease severity and its mechanistic contribution to atherosclerosis. Methodology: A case-control study with 138 subjects, including 88 (CAD) patients, and 50 apparently healthy individuals age between 40-75 years, was conducted. IL-17 level were measured using (ELISA) technique. Results: higher serum IL-17 concentration was significantly observed in patients (20.0567±4.4118 pg/ml) compared with that found in the apparently healthy group (12.9072±4.0378pg/ml) (P ≤ 0.0001). Serum IL-17 level had significant positive correlations with age, atherogenic index, lipid profile (Total cholesterol ,TG, LDL-C,VLDL-C . while showing significant negative correlations with high-density lipoprotein (HDL-C) levels in the CAD group. The results of the receiver operating curve (ROC) and AUC analysis for CETP as a potential diagnostic parameter showed a sensitivity of 79.10%, a specificity of 76%, and AUC 0.880 at a level of ≥ 16.0837pg/ml. Conclusion: elevated levels of serum IL-17 in the bloodstream may serve as a predictive indicator of the likelihood of developing CAD. which in go to increase the danger of developing CAD.

DOI

10.21608/ejmm.2024.308246.1295

Keywords

Coronary Artery Disease, IL-17, atherogenic index, and lipid profile

Authors

First Name

Douaa

Last Name

Kadhum

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, University of Kufa / Najaf, 54001– Iraq

Email

douaaabdul33@yahoo.com

City

najaf

Orcid

-

First Name

Muthanaa

Last Name

Mashkour

MiddleName

S.

Affiliation

Department of Chemistry, Faculty of Science, University of Kufa / Najaf, 54001– Iraq

Email

muthanasalih11@yahoo.com

City

najaf

Orcid

-

First Name

Hanaa

Last Name

Ali

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, University of Kufa / Najaf, 54001– Iraq

Email

hanaadaiali@yahoo.com

City

najaf

Orcid

-

First Name

Heshmatolah

Last Name

Parsian

MiddleName

-

Affiliation

Department of Physical Education and Sport Science, Shahre - e - Qods Branch, Islamic Azad University, Iran

Email

hashamatallahbari@yahoo.com

City

-

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-08-10

Publish Date

2024-10-01

Page Start

83

Page End

89

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 83-89.pdf

PDF . 426.5kB

Link

https://ejmm.journals.ekb.eg/article_375087.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=375087

Order

11

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of Interleukin-17 in the Pathogenesis and Progression of Coronary Artery Disease

Details

Type

Article

Created At

28 Dec 2024