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373053

Interleukin 17A -197 G/A gene polymorphism and interleukin-17 serum level in patients with Spondyloarthropathy

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Although the exact cause of spondyloarthropathy (SpA) is unknown, evidence points to the importance of interleukin-mediated immune responses 17A (IL-17A) in the progression of the condition. Objective: is to assess how IL17A gene polymorphism in the -197 G/A promoter region affects IL17 levels, disease severity, and treatment response in spondyloarthropathy patients. Methodology: A total of 65 Egyptians, 35 of them are patients with SpA, have been registered at the Aswan University Clinical Rheumatology department. Thirty healthy volunteers whose ages and sexes are matched to those of the patient group. Demographic information was given to each participant. Clinical examination, as well as a laboratory evaluation that included measuring the level of IL-17A in their serum using ELISA, Additionally, Extracted DNA was used for genotyping. Results: Of our cases, 17 patients (48.57%) were females and 18 were males (51.43%) In our investigation, the serum IL-17A levels of the patients and the controls differed significantly. The patients' levels of IL-17 were significantly higher in SpA than the controls'. The level of IL-17A in SpA was significantly correlated with either its active state (AS or PsA) or its sub-tyes, with a distinct cutoff point. The genotyping results for IL 17A -197 G/A in patients and the control group did not differ significantly.conclusion, our research suggests that IL-17A is a low-cost valued, and practical biomarker for identifying SpA in patients without symptoms and helps in early diagnosis of the disease to prevent development of  disabilities.

DOI

10.21608/ejmm.2024.304383.1277

Keywords

spondyloarthropathy, IL-17, Psoriasis, IL17A -197 G/A, Gene polymorphism

Authors

First Name

Ehab

Last Name

Fahmy

MiddleName

M.

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine, Helwan University

Email

ehabfahmy000@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Nageeb

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Aswan University

Email

h_nageeb2010@yahoo.com

City

Aswan

Orcid

-

First Name

Ahmed

Last Name

Sadek

MiddleName

-

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University

Email

ahmedsadek1945@yahoo.com

City

Assiut

Orcid

-

First Name

Fatma

Last Name

El Nouby

MiddleName

H.

Affiliation

Department of Rheumatology, Faculty of Medicine, Assiut University

Email

fatmanoby@yahoo.com

City

-

Orcid

-

First Name

Loay

Last Name

Aglan

MiddleName

I.

Affiliation

Department of Rheumatology, Faculty of Medicine, Aswan University

Email

quraa2015@yahoo.com

City

Aswan

Orcid

-

First Name

Asmaa

Last Name

Ibrahim

MiddleName

F.

Affiliation

Department of Clinical and Chemical pathology, Faculty of Medicine, Beni-Suef University

Email

dr.asmaafb88@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Amin

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Aswan University

Email

mohamedquraa@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-07-15

Publish Date

2024-10-01

Page Start

47

Page End

54

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 47-54.pdf

PDF . 411.3kB

Link

https://ejmm.journals.ekb.eg/article_373053.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=373053

Order

6

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Interleukin 17A -197 G/A gene polymorphism and interleukin-17 serum level in patients with Spondyloarthropathy

Details

Type

Article

Created At

28 Dec 2024