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371119

Serum level of IL22 and IL17 in recalcitrant common warts

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Recalcitrant warts are defined as warts persistent for longer than two years in spite of proper use of appropriate treatment. The interleukin-17 (IL-17) family cytokines have an essential protective role in host immune response to infection. IL-22 production is upregulated by NK and CD4 + T cells secondary to different types of viral infections throughout which IL-22 causes an essential role in the antiviral defense mechanism. Objectives: The aim of this study was to measure the level of IL-22 and Il-17 in recalcitrant common warts and healthy controls in an attempt to explain their role in wart pathogenesis. Methodology:  This was a case control study conducted on 50 patients with recalcitrant warts, and 40 healthy controls. All cases were subjected to history taking, physical examination and laboratory investigations comprising serum IL22 and IL 17 levels. Results:  Cases showed significantly lower IL-17 and IL22 levels in comparison with the control group. (p<0.001). Moderate accuracy was found for IL22 and IL17 to discriminate between cases and control groups. In addition, both IL-17 and IL-22 could be used for prediction of recalcitrant warts susceptibility (p<0.001). Conclusion:  Cases with recalcitrant warts were associated with significant decreases in serum IL-22 level, and this low level may have a potential function in improving the cell-mediated immune response towards HPV infections. Patients with recalcitrant warts were associated with significant reductions in serum IL-17 value; IL-17 deficiency plays a main role in recalcitrant wart pathogenesis via disturbance of the balance of the immune system and deficiency of immune cells. As a result, IL-17 may have an essential role in the antiviral immune response to HPV infection.

DOI

10.21608/ejmm.2024.304917.1278

Keywords

common warts, IL22, IL17

Authors

First Name

Asmaa

Last Name

Hussin

MiddleName

N.H

Affiliation

Department of Dermatology, New Mansoura Hospital, Mansoura, Egypt

Email

dr.asmaanabil91@gmail.com

City

-

Orcid

-

First Name

Elshahat

Last Name

Sharaf

MiddleName

F.A.

Affiliation

Department of Dermatology, Andrology & STDs, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

shahatfarag@gmail.com

City

mansoura

Orcid

-

First Name

Nessma

Last Name

Nosser

MiddleName

A.A.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

nessma_nosser@mans.edu.eg

City

mansoura

Orcid

-

First Name

Fatma

Last Name

El Dakrory

MiddleName

F.

Affiliation

Department of Dermatology, Andrology & STDs, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

tema_faisal86@yahoo.com

City

mansoura

Orcid

0009-0009-6548-891x

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-07-16

Publish Date

2024-10-01

Page Start

29

Page End

37

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 29-37.pdf

PDF . 438.1kB

Link

https://ejmm.journals.ekb.eg/article_371119.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=371119

Order

4

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Serum level of IL22 and IL17 in recalcitrant common warts

Details

Type

Article

Created At

28 Dec 2024