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369341

Klebsiella pneumoniae in Neonatal Sepsis: A Growing Challenge of Multidrug Resistance in a Tertiary Care Setting

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Neonatal sepsis, a potentially fatal medical condition marked by systemic infection in newborns, poses a substantial challenge for paediatricians and infection control professionals, particularly when attributed to Klebsiella pneumoniae (K. pneumoniae). Objectives: This research was designed to determine the predominant bacterial species causing late-onset neonatal sepsis (LONS) in the NICUs located at hospitals of Tanta University. The study specifically focused on evaluating the incidence of Klebsiella pneumoniae (K. pneumoniae) among these cases. Additionally, the research sought to conduct a comprehensive analysis of the phenotypes, antibiotic resistance profiles, antimicrobial resistance patterns, and of resistance mechanisms observed in K. pneumoniae isolates. Methodology: This study enrolled 100 neonates presenting with signs and symptoms of sepsis after 72 hours of birth. Standard microbiological techniques were employed for bacterial identification, with K. pneumoniae isolates confirmed through a series of biochemical reactions. The string test method was utilized to identify hypervirulent K. pneumoniae (hvKp) isolates. The determination of antibiotic susceptibility was carried out using the disc diffusion method and the colistin broth disk elution method. Results: Blood culture analysis revealed sepsis in 37% of the enrolled neonates. K. pneumoniae was identified as the predominant pathogen, responsible for 40.5% of these cases, with Staphylococcus aureus identified in 27%. Among the K. pneumoniae isolates, 33.3% were hvKp, and a significant proportion exhibited resistance: 53.3% were multidrug-resistant (MDR), 46.7% were extensively drug-resistant (XDR), and 86.7% were carbapenem-resistant (CRKP). Colistin and tigecycline demonstrated the highest efficacy against these resistant isolates. Conclusion: The substantial prevalence of K. pneumoniae in LONS underscores the critical need for robust infection control measures

DOI

10.21608/ejmm.2024.303818.1276

Keywords

HCAI, LONS, HVKP, XDR, CRKP

Authors

First Name

Aya

Last Name

Radwan

MiddleName

G.

Affiliation

Medical Microbiology & Immunology, Faculty of Medicine, Tanta University, Egypt

Email

ayagaber11816@gmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Shaheen

MiddleName

M.

Affiliation

Medical Microbiology & Immunology, Faculty of Medicine, Tanta University, Egypt

Email

asmaa.shahin@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Naglaa

Last Name

Ghonaim

MiddleName

F.

Affiliation

Medical Microbiology & Immunology, Faculty of Medicine, Tanta University, Egypt

Email

naglaa.ghonaim@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Wesam

Last Name

Amer

MiddleName

H.

Affiliation

Medical Microbiology & Immunology, Faculty of Medicine, Tanta University, Egypt

Email

wesam.amer@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Heba

Last Name

Elmahdy

MiddleName

S.

Affiliation

Pediatrics Medicine, Faculty of Medicine, Tanta University, Egypt

Email

heba.elmahdy@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Radwa

Last Name

Eissa

MiddleName

A.

Affiliation

Medical Microbiology & Immunology, Faculty of Medicine, Tanta University, Egypt

Email

radwa.eissa@med.tanta.edu.eg

City

Tanta

Orcid

-

Volume

33

Article Issue

4

Related Issue

49337

Issue Date

2024-10-01

Receive Date

2024-07-15

Publish Date

2024-10-01

Page Start

11

Page End

19

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 4_Pages 11-19.pdf

PDF . 408.2kB

Link

https://ejmm.journals.ekb.eg/article_369341.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=369341

Order

2

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Klebsiella pneumoniae in Neonatal Sepsis: A Growing Challenge of Multidrug Resistance in a Tertiary Care Setting

Details

Type

Article

Created At

28 Dec 2024