Background: Burn victims are susceptible to infections due to altered immune response and loss of skin integrity. Burn ICU patients are particularly susceptible to device-associated infections (DAI) such as catheter-associated urinary tract infections (CAUTI), central line-associated blood stream infections (CLABSI), and ventilator-associated pneumonia (VAP). The importance of prevention, and surveillance for these infections has been well established. Objectives: This study aimed to determine the incidence rates of DAI in the burn ICU unit of Ain Shams University Hospital together with assessment of compliance of healthcare workers (HCWs) to preventive bundles for VAP, CLABSI and CAUTI. Methodology: Prospective surveillance for DAI was conducted in burn ICU at Ain Shams University Hospitals between June 2022 to November 2022. The rates of VAP, CAUTI, and (CLABSI) were calculated following CDC definitions. Compliance to preventive bundles for VAP, CLABSI and CAUTI were measured using observation checklists. Results: CLABSI had the highest incidence (46.9/1,000 central line days) compared with VAP (44.4/1,000 ventilator days) and CAUTI (11.6/1,000 urinary catheter days). Compliance to VAP preventive bundle was the highest among HCWs; 96%. Compliance to CAUTI preventive bundle was 91.8% and 93% for insertion and maintenance bundles respectively. Compliance to insertion and maintenance bundles of central line preventive bundle were the least (51% and 54%, respectively). Conclusion: CLABSI was the most common infection among burn ICU patients. This could be attributed to poor compliance to prevention bundles. Therefore, educational strategies should focus on prevention of this life-threatening infection.