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363950

Assessment of H. pylori seropositivity in Multiple sclerosis and its relationship with disease severity in Egypt

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Studies have shown that H.Pylori might have a protective role in Multiple Sclerosis MS. However, there are inadequate and inconsistent epidemiological data regarding H. pylori serology among MS patients in Egypt. Objectives: We aim to measure and analyze the serum level of IgM and IgG of H. pylori among different clinical subsets of MS and to correlate it with the number of relapses, duration of disease, Disease Modifying Therapy DMT and Expanded Disability Status Scale EDSS. Methods: This is a case-control study that included 22 patients with SPMS secondary progressive multiple sclerosis and RRMS relapsing remitting multiple sclerosis and 22 control are recruited. The study comprised patients with a confirmed diagnosis of MS in accordance with the 2017 revisions to McDonald's criteria. Results: H. pylori immunoglobulin M IgM and IgG seropositivity in cases and control groups showed no significant difference among both groups. Conclusion: There was an insignificant association between the H. pylori antibodies and MS. Studies with a larger sample size are required to support our findings even more.

DOI

10.21608/ejmm.2024.298029.1266

Keywords

H. pylori, Multiple sclerosis, antibodies

Authors

First Name

Mohamed

Last Name

El-Samahy

MiddleName

-

Affiliation

Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Anani

MiddleName

M.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

mahaenany77@gmail.com

City

-

Orcid

-

First Name

Fadia

Last Name

Attia

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

fadiamostafa@gmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Abdulrehim

MiddleName

M.

Affiliation

Department of Internal Medicine, Faculty of Medicine (For Girls), Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Yasser

Last Name

Abdul

MiddleName

R.

Affiliation

Department of Gastroentrology, Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Dommita, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Gaber

MiddleName

-

Affiliation

Department of Endemic and Infectious diseases, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

agaber2006@yahoo.com

City

-

Orcid

-

First Name

Bassam

Last Name

Salama

MiddleName

M.

Affiliation

Department of Endemic and Infectious diseases, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

-

City

-

Orcid

-

First Name

Asmaa

Last Name

Hashem

MiddleName

A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abd-Elahady

MiddleName

E.

Affiliation

Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Fouad

MiddleName

A.

Affiliation

Department of Microbiology and Immunology Department, Faculty of Medicine, Benha University, Egypt

Email

-

City

-

Orcid

-

First Name

Naglaa

Last Name

Elwy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia-Egypt

Email

-

City

-

Orcid

-

Volume

33

Article Issue

3

Related Issue

47674

Issue Date

2024-07-01

Receive Date

2024-06-18

Publish Date

2024-07-01

Page Start

103

Page End

109

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 3_Pages 103-109.pdf

PDF . 319.7kB

Link

https://ejmm.journals.ekb.eg/article_363950.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=363950

Order

363,950

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Assessment of H. pylori seropositivity in Multiple sclerosis and its relationship with disease severity in Egypt

Details

Type

Article

Created At

28 Dec 2024