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363869

Evaluation of Manually Prepared Colistin Agar Performance against Gram Negative Organisms of Infected Cancer Patients in Egypt

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Introduction: Cancer patients are more vulnerable to infections because of changes affecting their immune system due to the cancer itself or the cancer treatment modalities, including surgery, radiation therapy, immunotherapy, and chemotherapy, either alone or in combination. Objectives: The study aimed to determine the rate and the type of infections in cancer patients during the cancer treatment journey and to evaluate the performance of the agar dilution method in testing for Colistin sensitivity by comparing automated and manual testing results. Methods: We conducted a cross-sectional study over 6 months, including 193 patients diagnosed with hematological and non-hematological malignancies and admitted to The National Cancer Institute, Cairo University. Collected data included demographic data of enrolled patients, prescribed antibiotics, lab investigations, cancer treatment &/or surgery. Microbiological data were collected and included types of samples, cultures requested, and isolated organisms with antibiotic susceptibility testing results, especially Colistin MIC and resistance pattern. Colistin agar was prepared and used for testing isolates against Colistin using three concentrations of Colistin Sulphate (4ug/L, 2ug/L, and 1ug/L). Results: Testing for Colistin sensitivity by MIC and agar dilution method showed a statistically significant association with a P value (<0.001).Conclusion: The agar dilution can be used as a manually accepted method to test for Colistin sensitivity.

DOI

10.21608/ejmm.2024.297406.1263

Keywords

The keywords: Infection, Cancer, Colistin, agar dilution

Authors

First Name

Dina

Last Name

Bassiouny

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

dinabassiouny009@gmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Mohammed

MiddleName

K.

Affiliation

Department of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt

Email

nohakamelmohammed@gmail.com

City

Cairo

Orcid

-

First Name

Nada

Last Name

Nawar

MiddleName

N.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nnabilnawar@yahoo.com

City

Cairo

Orcid

-

First Name

Samah

Last Name

Radwan

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt

Email

dr_samah_nci@yahoo.com

City

Cairo

Orcid

-

Volume

33

Article Issue

3

Related Issue

47674

Issue Date

2024-07-01

Receive Date

2024-06-20

Publish Date

2024-07-01

Page Start

87

Page End

93

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 3_Pages 87-93.pdf

PDF . 364.1kB

Link

https://ejmm.journals.ekb.eg/article_363869.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=363869

Order

363,869

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Evaluation of Manually Prepared Colistin Agar Performance against Gram Negative Organisms of Infected Cancer Patients in Egypt

Details

Type

Article

Created At

28 Dec 2024