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363364

Candiduria in Catheterized Children’s Patients: Association with UT, In-vitro Biofilm Formation, and Standardized VITEK 2 System for Isolated Candida Species

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Urinary tract infections (UTIs) by Candida species are becoming a common finding in hospitalized patients. Such association is higher in hospitalized pediatric patientsCandida albicans is the predominant fungal pathogen implicated in UTIs. Objective: This study aimed to demonstrate the prevalence of candiduria in pediatric patients with UTIs, characterize the Candida species involved, and evaluate their susceptibility to antifungal agents. Methodology: Candida species were isolated and identified in urine samples collected from 100 hospitalized children, comprising 76% from Inpatients' Units and 24% from Outpatients' Units, who were ranged in age from 25 days to 15 years. The automated VITEK 2 system was employed for both the identification of Candida species and susceptibility testing against various antifungal agents. Biofilm production from both albicans and non-albicans Candida was determined using the microtiter plate method. Results: Non-albicans Candida constituted more than half (52%) of the Candida isolates. A higher incidence of Candida species was observed in male patients from Inpatients' Units in the 1-5 years age group. Additionally, this study revealed a greater prevalence of Candida species among pediatric patients receiving antibiotic treatment. The seven identified Candida species exhibited varying sensitivity to antifungal agents. Biofilm formation was more prevalent in non-albicans Candida. Conclusion: Candida tropicalis was the most prevalent non-albicans Candida (40%), being the most prolific biofilm producer. Amphotericin B and Micafungin were the drug of choice according to their complete sensitivity pattern.

DOI

10.21608/ejmm.2024.292829.1253

Keywords

Key words Candida spp, Catheterization, Urinary tract infection, Children’s patients, Biofilm

Authors

First Name

Aya

Last Name

Husseiny

MiddleName

A.

Affiliation

Armed Forces Pharmaceutical Factory, Nahia Street - Boulak El Dakrour, Giza, Egypt

Email

specialistaya@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abou-Zeid

MiddleName

A.

Affiliation

Faculty of Science, Galala University, Galala City, Suez, Egypt; Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Yosra

Last Name

Hassan

MiddleName

M.

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Nevin

Last Name

Ibrahim

MiddleName

A.

Affiliation

Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

33

Article Issue

3

Related Issue

47674

Issue Date

2024-07-01

Receive Date

2024-05-26

Publish Date

2024-07-01

Page Start

77

Page End

85

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 3_Pages 77-85.pdf

PDF . 617.1kB

Link

https://ejmm.journals.ekb.eg/article_363364.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=363364

Order

363,364

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Candiduria in Catheterized Children’s Patients: Association with UT, In-vitro Biofilm Formation, and Standardized VITEK 2 System for Isolated Candida Species

Details

Type

Article

Created At

28 Dec 2024