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360257

Association of Acne Vulgaris and Helicobacter pylori Infection: A Case-control Study

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Acne Vulgaris (AV) is a common skin condition that affects people of all ages. Dermatologic disorders such as Behcet's disease (BD), Henoch-Schoenlein purpura, and psoriasis vulgaris (PV) have been linked to Helicobacter pylori (H.pylori). There is debate regarding the relationship between H. pylori infection and other dermatological conditions including AV. Objective: To evaluate the levels of H.pylori antigen (Ag) in cases with AV, to find out possible association of H. pylori with AV and its severity. Methodology: The sixty participants in this prospective case control study were divided into two groups: the case group, which consisted of 30 AV patients, and the control group, which also comprised 30 healthy controls (HC) of similar age and sex. Determination of acne severity was done using “global acne grading system". Fresh stool samples from each subject were sent to the laboratory for detection of H. pylori Ag by using rapid quantitative method which depends on FIA (Fluorescent Immunoassay) using automated analyzer Gotten device. Results: Half (50%) of the studied acne cases had severe degree acne, 30% had moderate degree acne and 20% mild degree acne. There was a statistically significant positive correlation between H. pylori antigen and either of acne severity and Global score. The H. pylori antigen did not significantly correlate with sex, domicile, occupation, or marital status in either of the two cases.The amount and expression of H. pylori antigen were statistically significantly correlated with acne severity. The H.pylori Ag expression showed a significantly higher expression in severe acne group (100%) compared to mild acne group (16.7%) and moderate group (11.1%). Conclusion: The results of this investigation showed a favorable correlation between H. pylori infection and both AV severity and global score. The H. pylori antigen has a modest sensitivity and specificity, making it capable of distinguishing between cases and control groups.

DOI

10.21608/ejmm.2024.292614.1252

Keywords

Fluorescent Immunoassay, Global acne grading system, Helicobacter pylori, and Acne vulgaris

Authors

First Name

Esraa

Last Name

Abd elhalem

MiddleName

A.

Affiliation

Dermatology Department, Ministry of Health, Egypt

Email

drderma28@gmail.com

City

-

Orcid

-

First Name

Youssef

Last Name

Youssef

MiddleName

E.

Affiliation

Dermatology Department, Andrology and STDs, Mansoura Medical College

Email

yousef_elbayoumy63@yahoo.com

City

mansoura

Orcid

-

First Name

Hosam Eldin

Last Name

Abdel Twab

MiddleName

A.

Affiliation

Clinical Pathology Department, Mansoura Faculty of Medicine

Email

hosamtwab@mans.edu.eg

City

mansoura

Orcid

-

First Name

Fatma

Last Name

El Dakrory

MiddleName

F.

Affiliation

Dermatology, Andrology & STDs Department, Mansoura, Faculty of Medicine, Mansoura Medical College

Email

tema_faisal86@yahoo.com

City

mansoura

Orcid

0009-0009-6548-891x

Volume

33

Article Issue

3

Related Issue

47674

Issue Date

2024-07-01

Receive Date

2024-05-25

Publish Date

2024-07-01

Page Start

43

Page End

48

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 3_Pages 43-48.pdf

PDF . 265.4kB

Link

https://ejmm.journals.ekb.eg/article_360257.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=360257

Order

360,257

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association of Acne Vulgaris and Helicobacter pylori Infection: A Case-control Study

Details

Type

Article

Created At

28 Dec 2024