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358941

Prevalence of Nasal Colonization with Methicillin-Resistant Staphylococcus aureus (MRSA) Among Children in an Egyptian Community

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Epidemiology

Abstract

Background: Nasal Staphylococcus aureus is asymptomatically and permanently colonizing up to one-third of the population. This may start during the first few days of life and can lead to infections. Objectives: This study aimed to identify MRSA nasal carriage among children in an Egyptian community, detection of antibiotic resistance, biofilm-formation along with the virulence genes found in MRSA isolates. Methodology: In this community-based cross-sectional study, a total of 200 nasal swabs were collected. Cefoxitin susceptibility testing was done for MRSA detection. The MRSA isolates underwent antibiotic susceptibility and biofilm-formation testing. Genes associated with biofilm formation and virulence in MRSA isolates were also explored. From the examined subjects, 133 carriers of S. aureus were identified. About half (51.8) % of these isolats were MRSA.  The majority of MRSA isolates [73.9% (n=51)] were found to be positive for clfA gene. The prevalence of icaD, fnbA, icaA, cna, icaC, and icaB genes were found to be 0%, 14.5%, 0%, 33.3%, 0%, and 44.9%, respectively. Conclusion: This study showed that the presence of biofilm-encoding genes positively affects biofilm production activity. According to this study, many healthy children had nasal colonization with S. aureus and MRSA that necessitates developing effective antibiotic usage in the community.

DOI

10.21608/ejmm.2024.290566.1248

Keywords

cna, clfA, fnbA, icaABCD, MRSA, nasal colonization

Authors

First Name

Enas

Last Name

Hefzy

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine Fayoum University

Email

emh01@fayoum.edu.eg

City

-

Orcid

-

First Name

Tharwat

Last Name

Radwan

MiddleName

E. E.

Affiliation

Botany Department, Faculty of Science, Fayoum University, Egypt.

Email

tsd00@gmail.com

City

-

Orcid

-

First Name

Aliaa

Last Name

Ibrahim

MiddleName

N. M.

Affiliation

Botany Department, Faculty of Science, Fayoum University, Egypt.

Email

lolonabil63@gmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Hefzy

MiddleName

M.

Affiliation

Medcare Hospital, Sharjah, UAE

Email

mmhefzy@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Khalil

MiddleName

A. F.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Egypt.

Email

maf04@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

3

Related Issue

47674

Issue Date

2024-07-01

Receive Date

2024-05-28

Publish Date

2024-07-01

Page Start

33

Page End

42

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 3_Pages 33-42.pdf

PDF . 442.0kB

Link

https://ejmm.journals.ekb.eg/article_358941.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=358941

Order

358,941

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence of Nasal Colonization with Methicillin-Resistant Staphylococcus aureus (MRSA) Among Children in an Egyptian Community

Details

Type

Article

Created At

28 Dec 2024