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351711

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Epstein Barr Virus (EBV) is associated with at least 1% of global cancers including nasopharyngeal cancer (NPC). The EBV DNA importance in the prediction of NPC has received little attention in non-endemic areas. Objective of the current study was to investigate the frequency of EBV in NPC patients compared to control of healthy individuals, and to study the relationship between EBV infection and clinicopathological and demographic characteristics. Methodology: A Case control study was conducted at the Hospital of Mansoura University. Fresh biopsies were collected from NPC patients and healthy controls over 2-years period between 2021 and 2023. After previous DNA extraction, real-time polymerase chain reaction was performed for EBV detection. Results: The study included a total of 28 patient biopsies proven NPC and 32 control individuals. A significantly higher prevalence of EBV in patients as compared with controls. The presence of the EBV infection was determined in half of the NPC patients and 6.3% of the control group. There was none statistically significant association between the presence of EBV and the clinicopathological features.  Conclusion: EBV is prevalent in the NPC cases compared with controls. Further studies with a larger sample size are required to determine the true burden of EBV-associated NPC in Egypt

DOI

10.21608/ejmm.2024.282807.1242

Keywords

Epstein-Barr virus infections, Nasopharyngeal carcinoma, Real-Time RT-PCR

Authors

First Name

Enas

Last Name

Youness

MiddleName

Faisal

Affiliation

Medical Microbiology and Immunology, Laboratory of Talkha General Hospital, Ministry of Health and Population, Mansoura, Egypt

Email

enasfaisal81@gmail.com

City

-

Orcid

28101011511844

First Name

Safaa

Last Name

EL-Ageery

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

safageery@gmail.com

City

Mansoura

Orcid

-

First Name

heba

Last Name

degla

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

heba_degla@mans.edu.eg

City

-

Orcid

-

First Name

Asser

Last Name

Sharkawy

MiddleName

-

Affiliation

Otolaryngeolgy department, Faculty of Medicine, Mansoura University, Egypt

Email

assersharkawy@yahoo.com

City

-

Orcid

-

First Name

Rasha

Last Name

El-Mahdy

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

rhehassan@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-04-14

Publish Date

2024-04-01

Page Start

147

Page End

153

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 147-153.pdf

PDF . 394.0kB

Link

https://ejmm.journals.ekb.eg/article_351711.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=351711

Order

351,711

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Detection of Epstein-Barr virus infections in Egyptian Nasopharyngeal Carcinoma patients

Details

Type

Article

Created At

28 Dec 2024