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MiR-34a-5p as a Diagnostic and Prognostic marker for Patients of Chronic Rhinosinusitis with Nasal Polyps.

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Diagnostics

Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a common disease in Ear, Nose, and Throat (ENT) practice that has a negative impact on quality of life, and also has a high relapse rate after endoscopic nasal surgery. Objectives: to detect the expression level of miR-34a-5p in CRSwNP patients and to assess its correlation with clinical and laboratory data. Methodology: This study is a controlled observational study that included 100 subjects (50 patients with CRSwNP and 50 healthy controls). Blood samples were drawn from all subjects. RNA extraction and detection of fold change of miR-34a-5p was performed using real-time PCR.  Results: A significant down-regulation of the miR34a-5p marker in CRSwNP patients was detected.  The median for the miR-34a5p marker was lower in patients suffering from facial pain and severe nasal obstruction. Patients with nasal polyps that were large enough to protrude outside the middle meatus had significantly lesser levels of the miR-34a-5p marker. Conclusion: The down-regulation of miR-34a-5p level may regulate the pathogenesis and development of nasal polyps in CRSwNP patients clarifying miR-34a-5p role as new a biomarker and suggesting future research giving the chance to innovation of a new drug to up-regulate the miR34a-5p to its normal expression level.

DOI

10.21608/ejmm.2024.281426.1239

Keywords

Chronic rhinosiusitis, Nasal polyps, biomarker, miR-34a-5p

Authors

First Name

Sherif

Last Name

Guindi

MiddleName

-

Affiliation

Departments of Otorhinolaryngology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

ssg03@fayoum.edu.eg

City

-

Orcid

-

First Name

Qotb

Last Name

Mohamed

MiddleName

-

Affiliation

Departments of Otorhinolaryngology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

mohamedqotb@gmail.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Ali

MiddleName

M

Affiliation

Departments of Otorhinolaryngology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

mmm33@fayoum.edu.eg

City

-

Orcid

-

First Name

Sylvana

Last Name

Gaber

MiddleName

N.

Affiliation

Medical Microbiology and Immunology Fayoum University Faculty of Medicine

Email

sng00@fayoum.edu.eg

City

-

Orcid

-

First Name

Omayma

Last Name

Abdelaleem

MiddleName

O.

Affiliation

Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

dr.omayma@yahoo.com

City

-

Orcid

-

First Name

Mohammad

Last Name

Bahi

MiddleName

-

Affiliation

Departments of Otorhinolaryngology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

mohammed.bahi81@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-04-09

Publish Date

2024-04-01

Page Start

139

Page End

146

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 139-146.pdf

PDF . 387.7kB

Link

https://ejmm.journals.ekb.eg/article_350984.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=350984

Order

350,984

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

MiR-34a-5p as a Diagnostic and Prognostic marker for Patients of Chronic Rhinosinusitis with Nasal Polyps.

Details

Type

Article

Created At

28 Dec 2024