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345486

Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Diabetic nephropathy, a chronic kidney disease resulting from diabetes mellitus microvascular complications, is thought to be the primary cause of end-stage renal failure. Gene mutations affecting the TNF gene can impact the generation of tumor necrosis factor-α (TNF-α), which has been associated with worse clinical outcomes in patients with diabetic nephropathy who are in severe condition. Objective: The purpose of this study was to assess the relationship between diabetic nephropathy and TNFα -308 G/A gene polymorphism in individuals with diabetes. Methodology:  50 diabetic individuals were recruited in this case-control research and were split into two groups: 25 patients with nephropathy and 25 patients without nephropathy. As a typical control group, a third set of blood donors (n = 25) appeared to be in good condition. Patients' information was gathered through the use of an interview questionnaire. The test for gene polymorphism was PCR. The TNF α308 G/A gene's A allele has a positive, statistically significant correlation (P-value ~0.05) with DN. Results: The prevalence of DN among the study participants may be predicted by the presence of an A allele in the TNF α308 G/A gene with a statistically significant P-value (P-value < 0.05). The study participants' TNF α308 G/A gene patterns and albumin/creatinine ratio did not exhibit a statistically significant relationship. Conclusion: According to this study, having an A allele in the TNF α308 G/A gene may contribute to the pathophysiology of diabetic nephropathy and be a predictor of nephropathy in diabetic populations.

DOI

10.21608/ejmm.2024.345486

Keywords

TNF- α, Type 2 Diabetes, diabetic nephropathy, TNFα -308 G/A, Polymorphism

Authors

First Name

Nashwa

Last Name

Hassan

MiddleName

R.

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

nashwa.ramadan2011@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Nasr El Dien

MiddleName

F.

Affiliation

Internal Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

emy_nasr55@yahoo.com

City

-

Orcid

-

First Name

Rania

Last Name

Kishk

MiddleName

M.

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

raniakishk@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Hasnaa

Last Name

Azab

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

hasnaa.azab1985@gmail.com

City

ismailia

Orcid

-

First Name

Alyaa

Last Name

Othman

MiddleName

E.

Affiliation

Department of Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

alyaa_tm@yahoo.com

City

ismailia

Orcid

-

First Name

Basma

Last Name

Abdelaziz

MiddleName

M.

Affiliation

Family Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

basma_mohamed@med.suez.edu.eg

City

ismailia

Orcid

-

First Name

Sara

Last Name

Aboelros

MiddleName

A.

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

sara.abelros@yahoo.com

City

Ismailia

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-03-12

Publish Date

2024-04-01

Page Start

67

Page End

72

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 67-72.pdf

PDF . 468.2kB

Link

https://ejmm.journals.ekb.eg/article_345486.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=345486

Order

345,486

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of Tumor Necrosis Factor Alpha Gene Polymorphism (TNFα -308 G/A) and Prediction of Diabetic Nephropathy

Details

Type

Article

Created At

28 Dec 2024