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340945

Role of Candida Albicans Germ Tube Antibody Test in Diagnosis of Invasive Candidiasis in Intensive Care Unit at Beni-Suef University Hospital

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Candida species are common human commensals can cause wide range of ailments. The most serious is a spread serious infection, which happens with expanded pervasiveness in emergency unit patients. Authoritative diagnosis relies upon isolation of Candida from blood culture or positive cultures from other normally sterile body sites, yet this may recognize less than half of cases. Improved diagnostics are expected to control inception of antifungal treatment to diminish mortality rate. Objective: The aim of this study was to evaluate the potential utility of the CALB gene recognition PCR and the Candida albicans germ tube antibody test (CAGTA) as biomarkers for quickly identifying invasive candidiasis in patients who were in danger of developing the disease in emergency departments. Methodology: The study included 50 patients from ICU suffering from invasive Candida infection. For all patients, blood culture, CAGTA test and PCR for identification of CALB gene were done. Results: Taking blood culture as the gold standard for diagnosis of invasive candidiasis. The sensitivity of CAGT was 75% and the specificity was 88.1% while the sensitivity of PCR was 100% and the specificity was 83.3%. Conclusion: For the diagnosis of an invasive candida infection, the biomarkers PCR and CAGT have additional value.

DOI

10.21608/ejmm.2024.340945

Keywords

Invasive candidiasis, Candida albicans germ tube antibody, PCR

Authors

First Name

Nesreen

Last Name

Kamel

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni -Suef University, Beni-Suef, Egypt

Email

nsreen_walid@yahoo.com

City

Beni-Suef

Orcid

0000-0002-7673-0697

First Name

Sara

Last Name

Morsy

MiddleName

A.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni -Suef University, Beni-Suef, Egypt

Email

dr_sara15@yahoo.com

City

Beni-Suef

Orcid

-

First Name

Ahmed

Last Name

Azmy

MiddleName

F.

Affiliation

Department of Microbiology Faculty of Pharmacy, Beni -Suef University, Beni-Suef, Egypt

Email

ahmed.abdelaziz@pharm.bsu.edu.eg

City

Beni -Suef

Orcid

-

First Name

Eiman

Last Name

AbdulRahman

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology (Clinical Microbiology) Faculty of Medicine - Cairo University, Cairo, Egypt

Email

eimanmousa@yahoo.com

City

cairo

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-02-11

Publish Date

2024-04-01

Page Start

45

Page End

50

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 45-50.pdf

PDF . 272.7kB

Link

https://ejmm.journals.ekb.eg/article_340945.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=340945

Order

340,945

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of Candida Albicans Germ Tube Antibody Test in Diagnosis of Invasive Candidiasis in Intensive Care Unit at Beni-Suef University Hospital

Details

Type

Article

Created At

28 Dec 2024