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338126

Correlation between IL-17, TGF-β and PTPN-22 Levels and Covid-19 Severity in Patients with and without Autoimmune Diseases

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: The Coronavirus pandemic is the most significant global health crisis of our era. Since it first appeared in late 2019, the virus has spread to every continent. Furthermore, systemic inflammation is a common feature in many autoimmune diseases, increasing the risk of cardiovascular and thromboembolic diseases, which have also been linked to COVID-19. Objectives: This study aimed to identify the expression of IL-17 and TGF-β as predictors of COVID-19 severity in patients with and without autoimmune disease. Additionally, the study sought to investigate the role of protein tyrosine phosphatase non-receptor type 22 (PTPN-22) in the progression of COVID-19 in patients with autoimmune disease. Methodology: The study involved 52 COVID-19 patients, 26 having autoimmune disease and 26 not having any known autoimmune disease, along with 26 healthy controls. The expression levels of Il-17, TGF-β, and PTPN-22 were determined using the qRT-PCR technique. Data was collected and analyzed using SPSS. Results: Levels of IL-17 and PTPN-22 were significantly elevated in non-autoimmune COVID-19 patients, while TGF-β levels were significantly higher in the autoimmune group. Furthermore, all markers showed significant correlations with various laboratory biomarkers in both groups. Conclusion: The study found that IL-17 and PTPN-22 were significantly upregulated in patients without autoimmune inflammatory diseases (AID), with IL-17 showing strong correlations with inflammation and coagulation markers. Pro-inflammatory cytokines, including IL17A, were found to have the strongest association with COVID, and their levels may serve as potential risk factors for the severe progression of COVID to acute respiratory distress syndrome (ARDS).

DOI

10.21608/ejmm.2024.338126

Keywords

COVID-19, autoimmune diseases, PTPN-22

Authors

First Name

Fatma El zahraa

Last Name

Elaskalany

MiddleName

H.

Affiliation

Department of Microbiology, Faculty of Pharmacy, Assiut University

Email

elaskalanyf@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Microbiology, Faculty of Medicine, Assiut University

Email

mona-a-hassan@hotmail.com

City

أسيوط

Orcid

-

First Name

Michael

Last Name

Agban

MiddleName

N.

Affiliation

Department of Microbiology, Faculty of Medicine, Assiut University

Email

agbanmichael@aun.edu.eg

City

-

Orcid

-

First Name

Amal

Last Name

Elkhawaga

MiddleName

A.

Affiliation

Department of Microbiology, Faculty of Medicine, Assiut University

Email

amy.elkhawaga@aun.edu.eg

City

-

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-01-24

Publish Date

2024-04-01

Page Start

27

Page End

35

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 27-35.pdf

PDF . 562.2kB

Link

https://ejmm.journals.ekb.eg/article_338126.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=338126

Order

338,126

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Correlation between IL-17, TGF-β and PTPN-22 Levels and Covid-19 Severity in Patients with and without Autoimmune Diseases

Details

Type

Article

Created At

28 Dec 2024