Beta
ManageSearchChatDiscover
338125

Role of Interleukin-6 and Tumor Necrosis Factor-Alpha Genes Polymorphisms in COVID-19 Progression

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Background: IL6 and tumor necrosis factor-ɑ (TNF-ɑ) are important cytokines that determine the host defense mechanism, that play a pivotal role in COVID-19 progression. Objectives: To conclude the relation of IL6 174G/C and TNF-ɑ G/A different genotypes with COVID-19 progression, and investigate the relation between IL6 174G/C gene polymorphism and IL6 serum level in COVID-19 patients. Methodology: A total of 100 patients, divided into three groups, participated in the present study. IL6 rs1800795 (174G/C gene) genotypes were investigated by Mutagenically Separated PCR (MS-PCR) technique, and TNF α rs1800629 (308 G/A gene) genotypes were investigated by RFLP- PCR. Results: As regards IL6 genotypes, GC genotype is thought to be related to COVID-19 severity as it was only present among the moderate and severe groups, and GG genotype was predominant among the mild group more than the moderate and severe groups (P-value <0.05). TNF-ɑ genotypes; AA genotype may be a risky as it wasn't represented in the mild group, and was more predominant in the moderate and severe groups, also GG genotype may be protective as it was detected only in the mild group (P-value <0.05). IL6 C/G genotype was related to high IL6 serum level more than G/G genotype (P value< 0.001). Conclusion: IL6 and TNF-ɑ genotypes are related to COVID-19 progression. High IL6 serum level was related to IL6 C/G genotype, and this may play a role in COVID-19 progression.

DOI

10.21608/ejmm.2024.338125

Authors

First Name

Enas

Last Name

Ghoneim

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

enasghoniem@yahoo.com

City

Shebin El-Kom

Orcid

-

First Name

Ashraf

Last Name

Abd El Raouf Khalil

MiddleName

-

Affiliation

Clinical Biochemistry and Molecular Diagnostics, National Liver Institute - Menoufia University

Email

ashkalil2010@gmail.com

City

-

Orcid

-

First Name

Bishoy

Last Name

Berzy Tawadros

MiddleName

-

Affiliation

Chest Diseases and Tuberculosis, Faculty Medicine, Menoufia University

Email

berzybishoy@gmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Mahmoud Omar

MiddleName

E.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

asmaa.omar@liver.menofia.edu.eg

City

Sadat city, Menoufia

Orcid

-

First Name

Samah

Last Name

Awad

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

samahawad2016@yahoo.com

City

Menoufia

Orcid

-

Volume

33

Article Issue

2

Related Issue

45766

Issue Date

2024-04-01

Receive Date

2024-01-24

Publish Date

2024-04-01

Page Start

19

Page End

26

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 2_Pages 19-26.pdf

PDF . 617.0kB

Link

https://ejmm.journals.ekb.eg/article_338125.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=338125

Order

338,125

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of Interleukin-6 and Tumor Necrosis Factor-Alpha Genes Polymorphisms in COVID-19 Progression

Details

Type

Article

Created At

28 Dec 2024