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333956

Bisphenol A Effect on T regulatory and T helper 17 Related Cytokines in Female Mice

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Last updated: 28 Dec 2024

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Abstract

Background: In recent years there has been increasing concern about the potential health effects of exposure to Bisphenol A, especially in pregnant women and their offspring. The potential health effects of BPA exposure have been studied extensively in animal models. There is evidence to suggest that exposure to this compound can have a range of adverse health effects, including reproductive and developmental malformations, metabolic disorders, and immune dysfunction. Objectives: To determine the effect of Bisphenol A consumption on regulatory T cells and Th17 cell-associated cytokines in female mice, as well as whether Bisphenol A exposure could cause abortion in pregnant mice. Methodology: The study included 60 female mice divided into four groups; each group contained 15 female mice. The first group is the control, non-pregnant female mice, which take water containing 1% ethanol. The second group, female mice who aren҆t pregnant, which given 5 mg/ml/kg of a BPA solution. The third group is a control group of pregnant female mice who take water containing 1% ethanol. The fourth group, pregnant female mice, were given 5 mg/ml/kg of BPA solution. At the end of the trial, blood samples were taken and serum concentrations of Il-10, TGF-beta, and IL-17 were measured using ELISA kits. Results: In both pregnant and non-pregnant female mice, the experimental group exposed to BPA had considerably lower levels of TGF-beta and -IL-10 than the control group. Simultaneously, the experimental group had significantly higher levels of IL-17 than the control group. There was also a substantial change in TGF-beta, IL-10, and IL-17 levels between non-pregnant and pregnant mice. Conclusion: BPA exposure during pregnancy can result in aberrant T reg. and Th 17 cell-related cytokines and abortion in female mice.

DOI

10.21608/ejmm.2024.333956

Keywords

bisphenol A, T Regulatory cells, Abortion, Mice, Th 17 cells

Authors

First Name

Doaa

Last Name

Thabet

MiddleName

M.A

Affiliation

Department of Microbiology, Faculty of Pharmacy, Assiut University

Email

doaashraf92@gmail.com

City

Assuit

Orcid

Doaa M Ashraf

First Name

Mohamed

Last Name

Badary

MiddleName

S.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University

Email

diatechnology@yahoo.com

City

Assuit

Orcid

-

First Name

Maggie

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University

Email

maggie.abdallah@hotmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Nafee

MiddleName

M.A.M.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University

Email

amanynafeh@yahoo.com

City

Asyut

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2024-01-02

Publish Date

2024-01-01

Page Start

137

Page End

144

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 137-144.pdf

PDF . 402.8kB

Link

https://ejmm.journals.ekb.eg/article_333956.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=333956

Order

333,956

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Bisphenol A Effect on T regulatory and T helper 17 Related Cytokines in Female Mice

Details

Type

Article

Created At

28 Dec 2024