Beta
ManageSearchChatDiscover
332174

Association between Helicobacter pylori and Autoimmune Diseases Involving Type 1 Diabetes Mellitus and Autoimmune Thyroiditis

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Since the discovery of the harmful effects of Helicobacter pylori (H. pylori) and its initial discovery in the stomach, contemporary gastroenterology has made significant advancements. Epidemiological statistics indicate that autoimmune illnesses are more common when certain bacteria are infective or afterward. Studies have shown that H. pylori may be linked to different autoimmune disorders and that it may be a trigger for stomach autoimmunity. This study examines the current evidence supporting or refuting the theory that H. pylori may be a triggering factor for autoimmune disorders, such as type 1 diabetes mellitus and autoimmune thyroiditis. Methodology: Our study involved 180 participants divided into three equal groups including healthy control subjects, type 1 diabetes mellitus patients and autoimmune nondiabetic thyroid cases. All groups were subjected to blood sampling for measurement of Glycated hemoglobin A1c, thyroid stimulating hormone (TSH), free thyroxine (FT4), anti-H. pylori antibodies and cytokines multiplex test including IL-2, IL 18, and IFN gamma. Result: Serum IgG anti-H. pylori antibodies,  IL 18,  IFNγ levels showed higher levels while serum IL 2 level showed lower levels in autoimmune patients. Conclusions: Based on the aforementioned study, we conclude that H. pylori infection is one of the main environmental factors that contribute to multiple autoimmune illnesses.

DOI

10.21608/ejmm.2024.332174

Keywords

Helicobacter pylori- autoimmune disease- Type 1 Diabetes Mellitus – autoimmune thyroiditis, Cytokines

Authors

First Name

Essraa

Last Name

Hegazy

MiddleName

A.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

essraa.hegazy@gmail.com

City

HADAYEK EL HARAM , GIZA

Orcid

0000000304518416

First Name

Rania

Last Name

Talaat

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Helwan University, Cairo, Egypt

Email

rantalaat@yahoo.com

City

-

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-12-25

Publish Date

2024-01-01

Page Start

129

Page End

136

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 129-136.pdf

PDF . 407.7kB

Link

https://ejmm.journals.ekb.eg/article_332174.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=332174

Order

332,174

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association between Helicobacter pylori and Autoimmune Diseases Involving Type 1 Diabetes Mellitus and Autoimmune Thyroiditis

Details

Type

Article

Created At

28 Dec 2024