Beta
ManageSearchChatDiscover
332173

Prevalence and Antibiotic Resistance Patterns of Multidrug-Resistant (MDR) Bacteria Isolated from Pediatric Intensive Care Units

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: The escalating prevalence of antibiotic-resistant organisms, coupled with limited discovery efforts of novel drugs, poses a critical challenge. Particularly pediatrics are at an elevated risk, making periodic updates on antibiotic resistance data essential. Objective: This study aimed to determine the current prevalence of MDR bacteria in different PICUs and analyze the distribution of MDR infections across different childhood stages at a specialized University hospital in Cairo. Furthermore, we aim to detect the carbapenemase encoding genes in the CRE strains with the goal of highlighting the increasing rates of MDR infections especially in pediatric health care centers and increase awareness towards antibiotics usage. Methodology: In this study, 455 clinical samples were obtained from patients who were admitted to various pediatric ICUs. Samples were identified and tested for susceptibility to different antibiotics. Additionally, Enterobacteriaceae samples which had shown a potential carbapenemase activity were tested using multiplex PCR assay. Results: Our Results revealed that out of 318 bacterial samples, 290 (91%) were found to be MDR strains, 84 (92%) out of 91 Gram-positive isolates were MDR while out of 227 Gram-negative isolates 206 (90%) were MDR. Noticeably, neonates and toddlers are the most vulnerable age groups to the MDR infections with the percentage of 96.87% (31/32) and 95.5% (43/45), respectively. Conclusion: The study highlights the extensive prevalence of MDR bacteria in PICUs, emphasizing the urgent need for robust infection control measures and antibiotic stewardship programs.

DOI

10.21608/ejmm.2024.332173

Keywords

MDR, Pediatric, ICU, susceptibility, carbapenemases

Authors

First Name

Mennatallah

Last Name

Elghanam

MiddleName

-

Affiliation

Clinical Microbiology and Infection control Department, Cairo University Specialized Pediatric Hospital, Egypt

Email

mt.elghanam@gmail.com

City

-

Orcid

0009-0008-7503-0454

First Name

Mohamed

Last Name

Emara

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Helwan University, Egypt

Email

mohamed_emara@pharm.helwan.edu.eg

City

-

Orcid

0000-0001-7708-9435

First Name

Mona

Last Name

Abdelhalim

MiddleName

-

Affiliation

Clinical Microbiology and Infection control Department, Cairo University Specialized Pediatric Hospital, Egypt

Email

mona.mohiedden@kasralainy.edu.eg

City

-

Orcid

-

First Name

Walaa

Last Name

Moustafa

MiddleName

-

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Helwan University, Egypt

Email

walaa_hassan@pharm.helwan.edu.eg

City

-

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-12-25

Publish Date

2024-01-01

Page Start

119

Page End

128

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 119-128.pdf

PDF . 436.6kB

Link

https://ejmm.journals.ekb.eg/article_332173.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=332173

Order

332,173

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prevalence and Antibiotic Resistance Patterns of Multidrug-Resistant (MDR) Bacteria Isolated from Pediatric Intensive Care Units

Details

Type

Article

Created At

28 Dec 2024