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Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Elevated Galectin-3 (Gal-3) levels and Interleukin 33 (IL-33)/suppression of tumorigenicity 2 )ST2 (involved in the pathophysiology of incident chronic kidney disease (CKD), and renal fibrosis. Besides, IL-33 induces fibrosis of pulmonary, hepatic, skin, renal, and pancreatic tissues in a way that is dependent on ST2., whereas, plays a protective role against cardiac fibrosis and atherosclerosis. Objective: the aim of this study was to investigate the association between Gal-3 and the IL-33/ST2 axis with CKD severity and the incidence of associated multi-organ affection. Methodology: Eighty one subjects were enrolled in this study; 69 patients with CKD and 12 age- and sex-matched healthy controls. Disease severity was assessed by estimated glomerular filtration rate (eGFR), and patients were classified as having mild, moderate, or severe CKD. Serum Gal-3, IL-33, and sST2 were tested by ELISA and the expression level of Gal-3 was assessed by Real-time PCR. Results: Serum Gal-3, IL-33, ST2, and the Gal-3 gene expression levels significantly increased as the severity of CKD increases. Correlation analysis showed significant associations between serum creatinine, serum Gal-3, serum IL-33, serum ST2, and the Gal-3 gene level. Conclusion: Concentrations of Gal-3, IL-33, sST2, and the Gal-3 gene expression were directly proportional with the level of CKD severity highlighting the important role of these mechanisms in the progression of kidney disease. Accordingly, these biomarkers may be useful tools for disease monitoring and individualized therapies to slow the advancement of CKD as well as associated diabetes and heart disease.

DOI

10.21608/ejmm.2024.328915

Keywords

Chronic Kidney Disease (CKD), Galectin-3 (Gal-3), Interleukin 33 (IL-33), ST2

Authors

First Name

Rehab

Last Name

Shreet

MiddleName

O.

Affiliation

Urology Hospital, Faculty of Medicine , Assiut University, Assiut, Egypt

Email

rehab.shreet@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Embarek

MiddleName

S.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

monaembarek@aun.edu.eg

City

-

Orcid

0000-0003-2052-279X

First Name

Marwa

Last Name

KhairAllah

MiddleName

K.

Affiliation

Department of Nephrology and, Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

dr.marwakamal@aun.edu.eg

City

Assiut

Orcid

-

First Name

Sherine

Last Name

Aly

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

s-aly71@au.edu.eg

City

Assiut

Orcid

-

First Name

Safy

Last Name

Hadiya

MiddleName

-

Affiliation

Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut

Email

ph.s.h.1989@gmail.com

City

Assiut

Orcid

-

First Name

Ismail

Last Name

Soliman

MiddleName

S.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

ismailsoliman37@yahoo.com

City

Assiut

Orcid

-

First Name

Amal

Last Name

Elkhawaga

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

amy.elkhawaga@yahoo.com

City

Assiut

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-12-05

Publish Date

2024-01-01

Page Start

111

Page End

118

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 111-118.pdf

PDF . 475.4kB

Link

https://ejmm.journals.ekb.eg/article_328915.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=328915

Order

328,915

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

Details

Type

Article

Created At

28 Dec 2024