Beta
327382

Human Cytomegalovirus and COX2 Expression among Women with Breast Tumors

Article

Last updated: 05 Jan 2025

Subjects

-

Tags

Clinical microbiology

Abstract

Background: The human cytomegalovirus (HCMV) has been linked to all cancer characteristics, leading to increasing speculation that it plays a role in oncomodulation and human carcinogenesis. An increasing body of research demonstrates a connection between HCMV infection and a number of cancers, including breast cancer. Inflammatory cells produce chemokines, cytokines, and growth factors into the microenvironment of the tumor that encourage tumor growth and malignancy. Biopsies of breast cancer often showed COX-2 expression, which HCMV might be the cause of. Objectives: Our study aimed to through a beam of light on HCMV as a viral etiology of breast tumors and investigate the association between HCMV infection and simultaneous expression of COX2 in women with breast tumors. Methodology: We assessed HCMV DNA presence by nested type PCR and COX-2 by ELISA in breast tissues obtained from 33 breast cancer (BC) patients, 24 benign breast lesions, and 33 normal breast tissues. Results: We found that there was a statistically significant weak association between HCMV DNA in malignant, benign breast lesions and normal breast tissue groups (p=0.036) and (V =0.283). Also, there was a statistically significant difference between the studied malignant, benign breast lesions and normal breast tissue groups as regard median COX-2 (p =0.0088). In addition, presence of HCMV proteins (E/IE) was identified in 4 breast cancer tissue samples (25%), there was a weak positive correlation between HCMV viral proteins (E/IE) and COX-2 in group IA with statistically insignificant difference r= 0.26 and (p= 0.15). Conclusion: We concluded that the existence of CMV DNA and proteins in breast cancer (BC) tissues points to the virus's involvement. In addition, COX-2 may contribute to the development of BC.

DOI

10.21608/ejmm.2024.327382

Keywords

breast cancer, HCMV, human cytomegalovirus, Cox2

Authors

First Name

Aya

Last Name

Elnegery

MiddleName

A.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

ayaelnegery@mans.edu.eg

City

Mansoura

Orcid

-

First Name

Mohammad

Last Name

Abou elela

MiddleName

A.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

abouelela@hotmail.com

City

-

Orcid

-

First Name

Sahar

Last Name

Mohamed

MiddleName

T.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University and Horus University, Egypt

Email

-

City

-

Orcid

-

First Name

Omar

Last Name

Ragab

MiddleName

F.A.

Affiliation

Oncology Center, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Shaimaa

Last Name

Yussif

MiddleName

M.I.

Affiliation

Pathology Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Noha

Last Name

Abou El-Khier

MiddleName

T.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-25

Publish Date

2024-01-01

Page Start

73

Page End

82

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_327382.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=327382

Order

327,382

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Human Cytomegalovirus and COX2 Expression among Women with Breast Tumors

Details

Type

Article

Created At

28 Dec 2024