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327356

Prognostic value of Procalcitonin and Interleukin 6 in COVID-19 patients

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Diagnostics

Abstract

Background: The inflammatory response plays a critical role in (COVID-19), and inflammatory cytokine storm increases COVID-19 infection severity. Objective: To investigate the ability of interleukin-6 (IL-6) and procalcitonin (PCT) to predict COVID-19 disease severity. Methodology: Cross sectional analytic study included 55 patients diagnosed with COVID-19 Clinically, radiologically and confirmed by PCR, who were admitted in the Intensive Care Units of Al Kasr Al Ainy Isolation Hospitals from July 2020 to March 2021. The study population was divided into two groups according to disease severity: a moderate group (n=25) and a severe group (n=30). Data on the clinical characteristics, demographic characteristics, IL-6 and PCT levels were carefully collected. Results: Among our 55 patients, IL-6 and PCT levels were increased in 100 % and 27.3% of the patients respectively. The proportion of patients with elevated PCT levels was significantly high in the severe group when compared to the moderate group. Cox proportional hazard model demonstrated that PCT can be a significantly better method to detect the severity COVID 19 infection more than IL-6 (AUC (95% CI), P value = 0.696 (0.52- 0.87), 0.025 vs. 0.611 (0.461- 0.762), 0.201) respectively. Conclusion: IL-6 and PCT levels can be considered effective markers in the determination of COVID-19 severity and disease progression.

DOI

10.21608/ejmm.2024.327356

Keywords

Prognostic Value, Procalcitonin, Interleukin 6, COVID-19

Authors

First Name

Amira

Last Name

Shamseldin

MiddleName

M.

Affiliation

Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

amira.shams@yahoo.com

City

Giza

Orcid

-

First Name

Dalia

Last Name

Ismail

MiddleName

K.

Affiliation

Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

hoelwan@gmail.com

City

Giza

Orcid

-

First Name

Ahmed

Last Name

Mukhtar

MiddleName

M.

Affiliation

Anesthesiology and ICU, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

ahmed.mukhtar@kasralainy.edu.eg

City

Giza

Orcid

-

First Name

Sabrin

Last Name

Elkashef

MiddleName

M.M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University

Email

sabrinaelkashefmm@gmail.com

City

-

Orcid

-

First Name

Moushira

Last Name

Ezz El Arab

MiddleName

H.

Affiliation

Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

moushirahosny@kasralainy.edu.eg

City

Giza

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-25

Publish Date

2024-01-01

Page Start

65

Page End

71

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 65-71.pdf

PDF . 285.4kB

Link

https://ejmm.journals.ekb.eg/article_327356.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=327356

Order

327,356

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Prognostic value of Procalcitonin and Interleukin 6 in COVID-19 patients

Details

Type

Article

Created At

28 Dec 2024