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326879

Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: To assess the diagnostic role of serum complement factor H (CFH), complement factor D (CFD), and terminal complement complex (C5b-9) and urine C5b-9 in women diagnosed with preeclampsia (PE) and severe PE compared to normal pregnancy. Methodology: A cross-sectional study involved 89 women divided into three groups: Group I, thirty women with PE, and Group II, thirty women with severe PE. Group III consisted of twenty-nine women with normal pregnancies as a control group. Estimation of serum levels of CFH, CFD, C5b-9, and urine C5b-9 levels in different study groups was done by ELISA test. A correlation analysis was carried out between levels of complement factors, clinical data, and laboratory tests. Results: Serum CFD, CFH, C5b-9, and urine C5b-9 levels were significantly elevated in patients with PE and severe PE compared to a normal pregnancy (p <0.001). In addition, severe PE patients showed a significant increase compared to the PE group (p <0.001). A significant positive correlation was found between serum CFD, CFH, C5b-9, and urine C5b-9 with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patient groups. The accuracy of serum CFH, C5b-9, and urine C5b-9 in the diagnosis of severe PE was found to be 100%, while serum CFD had an overall accuracy of 98.9%. Conclusion: Serum CFH, CFD, C5b-9, and urine C5b-9 can serve as diagnostic markers for severe PE, aiding in early detection of high-risk patients, disease monitoring, and appropriate treatment.

DOI

10.21608/ejmm.2024.326879

Keywords

preeclampsia, complement, High risk pregnancy, Hypertension

Authors

First Name

Dina

Last Name

Assaf

MiddleName

M.

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut

Email

dinamahmoud@pharm.aun.edu.eg

City

Assiut

Orcid

-

First Name

Enas

Last Name

Deaf

MiddleName

A.

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut

Email

enasdeaf@aun.edu.eg

City

Assiut

Orcid

-

First Name

Shereine

Last Name

Elgendy

MiddleName

GG.

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut

Email

shereinelgendy@aun.edu.eg

City

Assiut

Orcid

-

First Name

Ahmed

Last Name

Abbas

MiddleName

M.

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut

Email

ahmedabbas@aun.edu.eg

City

Assiut

Orcid

-

First Name

Asmaa

Last Name

Shaltout

MiddleName

S.

Affiliation

Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut

Email

asmaashaltout@aun.edu.eg

City

-

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-21

Publish Date

2024-01-01

Page Start

49

Page End

56

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 49-56.pdf

PDF . 337.3kB

Link

https://ejmm.journals.ekb.eg/article_326879.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=326879

Order

326,879

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Assessment of the Diagnostic Value of the Terminal Complement Complex, Factor D and factor H in Preeclampsia

Details

Type

Article

Created At

28 Dec 2024