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326097

Characterization of Nosocomial Fungal Infection among Hepatic ICU Patients in National Liver Institute

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

prevention of hospital infections

Abstract

Background: Fungi now represent a serious worldwide threat especially in patients with comorbidities as liver diseases with association of high mortality rates. Regular assessment of at-risk patients, diagnosis by reliable methods in addition to knowledge about antifungal susceptibility and possible sources of such infection help to contain the spread of those life threating infections among high-risk hepatic ICU patients. Objective: Determination of the incidence, morbidity and mortality of nosocomial fungal infection in hepatic ICU patients, determination of the possible risk factors and antifungal susceptibility pattern in them, tracing possible sources of infection and finally assessment available disinfectants against fungi. Methodology: The study was conducted on 150 hepatic ICU patients after 48th hours from admission and also on their related environment. Fungal cultures and Multiplex PCR were done for isolation and species identification of the isolates and antifungal susceptibility and antifungal bio typing of suspected sources of infection were performed by VITEK 2 YST–AST cards and disc diffusion method different disinfectants were tested by sampling surfaces before and after disinfection. Results: The incidence of NFI among hepatic ICU patients was (23.3%) with high mortality (69%). The most significant risk factors were the presence of CVC, prolonged ICU stay, COVID infection, previous fungal colonization, antibiotics and corticosteroid exposure and total parenteral nutriton. The most predominant species were C.albicans (43%) with rising incidence of Non albicans (57%).Antifungal susceptibilities were variable with increasing incidence of Azoles resistance. HCWs hands were the most common source of infection (58%). Lysoformine and Chlorine were effective against environmental fungi (100% reduction).Conclusion:  NFI are obvious threat to hepatic ICU patients with high incidence and high mortality rates which is needed to be early diagnosed specifically to species level for proper antifungal targeting. Proper hand hygiene and environmental cleaning are the corner stone of prevention.

DOI

10.21608/ejmm.2024.326097

Keywords

Nosocomial, Candida, hepatic ICU, Aspergillus, Mucor, Multiplex PCR

Authors

First Name

Enas

Last Name

Ghoneim

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

enasghoniem@yahoo.com

City

Shebin El-Kom

Orcid

-

First Name

Azza

Last Name

Abd ElAziz

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

azzazoze@gmail.com

City

Menoufia

Orcid

-

First Name

eman

Last Name

Mahmoud

MiddleName

A.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

emanmahmoud289@gmail.com

City

-

Orcid

-

First Name

Samah

Last Name

Awad

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, National Liver Institute, Menoufia University

Email

samahawad2016@yahoo.com

City

Menoufia

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-14

Publish Date

2024-01-01

Page Start

25

Page End

36

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 25-36.pdf

PDF . 724.8kB

Link

https://ejmm.journals.ekb.eg/article_326097.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=326097

Order

326,097

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Characterization of Nosocomial Fungal Infection among Hepatic ICU Patients in National Liver Institute

Details

Type

Article

Created At

28 Dec 2024