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325650

Serum Soluble Interleukin–2 Receptor Alpha and RANTES Chemokine as Potential Biomarkers for COVID–19 Infection and Severity

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Last updated: 28 Dec 2024

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Host response

Abstract

Background: Even though it seems that the COVID-19 epidemic has ended, the threat of viral mutation and resurgence is still looming. The illness is characterized by acute respiratory distress and other symptoms caused by immune system disturbance and cytokine storm. Objective: We aimed to determine the serum level of soluble Interleukin – 2 Receptor alpha (IL-2Ra) and RANTES in COVID-19 patients. Methodology: A case-control study was performed on 60 patients with a positive nasopharyngeal swab tested by real-time PCR for SARS-CoV-2 and 25 healthy controls to measure serum levels of sIL-2Ra and RANTES using Enzyme-Linked Immunosorbent Assay. Results: The findings showed no significant difference in the serum levels of sIL-2Ra and RANTES between patients and healthy controls, nor was there a difference between severe and non-severe cases of COVID-19. A significant association was observed between the presence of a previous chest condition and the level of RANTES and a significant positive correlation was detected between serum sIL2Ra and RANTES levels. Conclusions: The study analyzed the correlation between the serum sIL2Ra and RANTES, being positively correlated means the same factors influence them and they can be therapeutically targeted in the same way. The effect of a pre-existing chest condition on RANTES level encourages regular monitoring of RANTES. Although the UN WHO has announced that the status of COVID-19 as a public health emergency has been lifted, the virus will always remain a worldwide threat. Therefore, comprehensive research should continue to be better prepared.

DOI

10.21608/ejmm.2024.325650

Keywords

sIL-2Ra, RANTES, ELISA, COVID-19

Authors

First Name

Dalia

Last Name

Labib

MiddleName

A.A.

Affiliation

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

labibdalia@yahoo.com

City

-

Orcid

-

First Name

Rasha

Last Name

Shahin

MiddleName

M.H.

Affiliation

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

rasha.shaheen@kasralainy.edu.eg

City

-

Orcid

-

First Name

Lamees

Last Name

Samy

MiddleName

A.

Affiliation

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

dr.lamees.samy@hotmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Elansary

MiddleName

G.

Affiliation

Critical Care Medicine, Faculty of Medicine, Cairo University

Email

mgelansary@kasralainy.edu.eg

City

-

Orcid

-

First Name

Nada

Last Name

Radwan

MiddleName

W.A.

Affiliation

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

nadaradwan44@gmail.com

City

-

Orcid

-

First Name

Hend

Last Name

Tamim

MiddleName

H.

Affiliation

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University

Email

hend.tamim@kasralainy.edu.eg

City

-

Orcid

0000-0001-8119-2187

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-11

Publish Date

2024-01-01

Page Start

11

Page End

17

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 11-17.pdf

PDF . 433.6kB

Link

https://ejmm.journals.ekb.eg/article_325650.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=325650

Order

325,650

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Serum Soluble Interleukin–2 Receptor Alpha and RANTES Chemokine as Potential Biomarkers for COVID–19 Infection and Severity

Details

Type

Article

Created At

28 Dec 2024