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325648

Value of Soluble CD14 (Presepsin) in Diagnosis of Bacterial Sepsis in Patients with Chronic Liver Disease

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Sepsis in chronic liver disease (CLD) patients with high mortality and morbidity rates. Therefore, early detection in these patients may improve prognosis of the disease. CD14 may be a promising biomarker in the diagnosis of sepsis. Objectives:  Our study aimed to evaluate presepsin (sCD14) as an early diagnostic marker in septic patients with CLD. Its value was compared to that of CRP, and total leucocytic count (TLC) for diagnosis of bacterial infection. Methodology: The study included 60 patients with sepsis in addition to 30 healthy subjects as controls. Complete blood count, CRP, liver and renal function tests as well as blood culture were performed. Identification of the isolated organisms and antibiotic susceptibility testing were performed using VITEK2 compact system and sCD14 was measured by ELISA. Results: Levels of sCD14 were significantly higher (P<0.001) in septic patients compared with controls. ROC curve revealed that the sCD14 had a higher diagnostic performance than that of CRP and TLC (P<0.001).  The sCD14, at cutoff level greater than 0.89 mg/L, had 91.67% sensitivity and 63.33% specificity. Conclusion: sCD14 is more sensitive and specific for diagnosis of sepsis compared with CRP and TLC.

DOI

10.21608/ejmm.2024.325648

Keywords

presepsin, Soluble Cd14, Chronic liver disease, Sepsis

Authors

First Name

Enas

Last Name

Ghoneim

MiddleName

M.

Affiliation

Clinical Microbiology & Immunology Department, National Liver Institute, Menoufia University-Shebin El-Kom-Egypt

Email

enasghoniem@yahoo.com

City

Shebin El-Kom

Orcid

-

First Name

Azza

Last Name

Abd ElAziz

MiddleName

M.

Affiliation

Clinical Microbiology & Immunology Department, National Liver Institute, Menoufia University-Shebin El-Kom-Egypt

Email

azzazoze@gmail.com

City

Shebin El-Kom

Orcid

-

First Name

Ahmed

Last Name

AbuAmer

MiddleName

M.

Affiliation

Hepatology Department, National Liver Institute, Menoufia University- Shebin El-Kom -Egypt

Email

abuamer76000@gmail.com

City

Shebin El-Kom

Orcid

-

First Name

Alaa

Last Name

Ghonaim

MiddleName

M.

Affiliation

Clinical Microbiology & Immunology Department, National Liver Institute, Menoufia University-Shebin El-Kom-Egypt

Email

alaaghoniam@liver.menofia.edu.eg

City

-

Orcid

0000-0001-7120-8317

First Name

Samah

Last Name

Awad

MiddleName

M.

Affiliation

Clinical Microbiology & Immunology Department, National Liver Institute, Menoufia University-Shebin El-Kom-Egypt

Email

samahawad2016@yahoo.com

City

Shebin El-Kom

Orcid

-

Volume

33

Article Issue

1

Related Issue

44331

Issue Date

2024-01-01

Receive Date

2023-11-11

Publish Date

2024-01-01

Page Start

1

Page End

10

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 33_Issue 1_Pages 1-10.pdf

PDF . 351.7kB

Link

https://ejmm.journals.ekb.eg/article_325648.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=325648

Order

325,648

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Value of Soluble CD14 (Presepsin) in Diagnosis of Bacterial Sepsis in Patients with Chronic Liver Disease

Details

Type

Article

Created At

28 Dec 2024