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321765

Association of rs6695096 Single Nucleotide Polymorphism of Human Mannose Binding Lectin Associated Serine Protease 2 (MASP2) Gene Locus and MASP2 Serum Level with Systemic Lupus

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background:  Systemic lupus erythematosus (SLE) represents one of the most challenging autoimmune diseases with high morbidities. MASP2 is a central enzyme in the lectin pathway of complement that has a potential role in the disease pathogenesis. This makes it a potential biomarker of interest in correlation with the disease activity. Objectives: The aim of the study was to assess the association between MASP2 serum level and SLE disease activity as well as the association between MASP2 rs 6695096 SNP and SLE. Methodology: Thirty-five patients diagnosed as SLE and Fifteen healthy control subjects were included in this study. The serum level of MASP2 was measured by ELISA and the rs 6695096 SNP of MASP2 was detected by PCR for both groups.  Results:  MASP2 serum levels were significantly lower in patients compared to control group (p=0.009). In addition, serum MASP2 level was negatively correlated with the disease activity (p=0.002). TC genotype was significantly correlated with pleural effusion (p=0.007) and hematuria (p=0.031). No significant correlation could be observed between MASP2 genotypes and both SLEDAI score and MASP2 serum level.  Conclusion: Decreased MASP2 level could be a promising biomarker of SLE disease activity.

DOI

10.21608/ejmm.2023.321765

Keywords

Systemic lupus erythematosus, MASP2, SNP

Authors

First Name

Dina

Last Name

Abu Shabana

MiddleName

S.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Egypt

Email

dina_samir156@med.asu.edu.eg

City

Cairo

Orcid

0009-0001-4580-768X

First Name

Mohamed

Last Name

Mohamed

MiddleName

R.

Affiliation

Rheumatology Department, Faculty of Medicine, Ain Shams University, Egypt

Email

drrezk2016@gmail.com

City

cairo

Orcid

0000-0001-6624-1614

First Name

Dina

Last Name

Erfan

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Egypt

Email

drdime03@yahoo.com

City

cairo

Orcid

0000-0002-9742-4584

First Name

Shereen

Last Name

Taha

MiddleName

E.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Egypt

Email

dr_shereentaha@med.asu.edu.eg

City

-

Orcid

0000-0003-3465-4494

First Name

Yasmin

Last Name

Ahmed

MiddleName

M.

Affiliation

Medical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Egypt

Email

dryasmin.mahmoud@med.asu.edu.eg

City

-

Orcid

0000-0002-1062-1738

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-10-16

Publish Date

2023-10-01

Page Start

85

Page End

94

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 85-94.pdf

PDF . 589.1kB

Link

https://ejmm.journals.ekb.eg/article_321765.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=321765

Order

321,765

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association of rs6695096 Single Nucleotide Polymorphism of Human Mannose Binding Lectin Associated Serine Protease 2 (MASP2) Gene Locus and MASP2 Serum Level with Systemic Lupus Erythematosus

Details

Type

Article

Created At

28 Dec 2024