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321198

Serum Melatonin in Early Onset Neonatal Sepsis

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Neonatal sepsis is the result of inflammatory and oxidative stress events leading to cellular oxidative damage. Endogenous melatonin is an antioxidant and free radical scavenger. The objective of this study is to evaluate serum melatonin level as a marker of early onset neonatal sepsis (EOS) in preterm infants. Methodology: Serum melatonin was measured in 20 preterm infants with EOS, and 20 healthy matched preterm controls on day1, then serum melatonin level was estimated in all patients 72 hours after the start of the empirical antibiotics. Results: There was a statistically significant positive correlation between serum melatonin and TLC, CRP, and I/T ratio (r= 0.7458, p=0.001) (r= 0.76, p = 0.01) (r= 0.758, p= 0.001) respectively after empirical antibiotic. Also, there was significant positive correlation between CRP percentage of change and serum melatonin percentage of change after antibiotics (r= 0.752, P<0.001). However, there was no statistically significant difference between patients' initial serum melatonin level and control. Also, there was no statistically significant correlation between initial patients' serum melatonin and initial hemoglobin, TLC, platelet count, I/T ratio, or CRP. Conclusion: Endogenous melatonin could not be used as a marker for EOS; however, it might be helpful in the follow up of preterm patients with EOS. 

DOI

10.21608/ejmm.2023.321198

Keywords

Neonatal sepsis, Melatonin, Oxidative Stress

Authors

First Name

Mohammed

Last Name

El Barbary

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

profbarbary@hotmail.com

City

Cairo

Orcid

-

First Name

Mostafa

Last Name

Mostafa

MiddleName

G.

Affiliation

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

dr.mostafagm2000@yahoo.com

City

Cairo

Orcid

-

First Name

Walaa

Last Name

Kabiel

MiddleName

A.Y.

Affiliation

Department of Clinical pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

walaa_willy@yahoo.com

City

Cairo

Orcid

-

First Name

Hebatallah

Last Name

Shaaban

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

heba_ali@med.asu.edu.eg

City

-

Orcid

-

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-10-12

Publish Date

2023-10-01

Page Start

77

Page End

83

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 77-83.pdf

PDF . 293.9kB

Link

https://ejmm.journals.ekb.eg/article_321198.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=321198

Order

321,198

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Serum Melatonin in Early Onset Neonatal Sepsis

Details

Type

Article

Created At

28 Dec 2024