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320067

Association of Serum Interlukin-6 and Transforming Growth Factor Beta with Response to Antiviral Therapy for Chronic Hepatitis C Patients

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Hepatitis C virus (HCV) infection is an important contributor for acute and chronic liver disorders. Drug acting antivirals (DAAs) are compounds; as sofosbuvir and daclatasvir; target HCV replication cycle to inhibit viral replication and promote gradual clearance of the virus by death of infected cells. Pro-inflammatory cytokines; as interleukin-6 (IL-6) and Transforming growth factor β (TGF- β); are induced by HCV viral dsRNA and proteins. Objective: To declare if there is a relationship between serum IL-6 and TGF- β levels and response to DDAs in chronic HCV patients. Methodology: Forty patients with Chronic HCV were involved. PCR for detection of viral activity was performed before treatment, 12 weeks after the end of treatment. According to PCR results, patients were divided into: 2 non-responders and 33 sustained virologic responders (SVR). 14 healthy individuals were included as a control group. Total bilirubin, direct bilirubin, albumin, AST, ALT, ALP, urea, creatinine, prothrombin time, prothrombin concentration and international normalization ratio (INR) were reported. The serum levels of IL-6 and TGF-β were measured using ELISA kits. Results: In patients with SVR and control groups, mean levels of ALT, AST, albumin, total bilirubin and ALP were within normal range. In naïve CHC patients, the mean levels of ALT, AST and total bilirubin were increased, but mean levels of albumin and ALP were within normal range.  IL-6 and TGF-β levels decreased significantly after treatment in SVR group. Conclusion: Virological response during HCV therapy was associated with decrease in IL-6 and TGF-β levels.

DOI

10.21608/ejmm.2023.320067

Keywords

Hepatitis C virus, IL-6, TGF- β, Sofosbuvir, Daclatasvir

Authors

First Name

Hayam

Last Name

Mahmoud

MiddleName

H.M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt

Email

hayamhamdy443@gmail.com

City

Assiut

Orcid

-

First Name

Salwa

Last Name

Seif Eldin

MiddleName

S.A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt; Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Saudi Arabia

Email

ssseifeldin@pnu.edu.sa

City

Assiut

Orcid

-

First Name

Sahar

Last Name

Nour

MiddleName

M.

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Egypt

Email

saharhassany@yahoo.com

City

Assiut

Orcid

-

First Name

Aliaa

Last Name

Ghandour

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt

Email

aliaaghandour@yahoo.com

City

Assiut

Orcid

-

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-10-04

Publish Date

2023-10-01

Page Start

61

Page End

69

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 61-69.pdf

PDF . 542.3kB

Link

https://ejmm.journals.ekb.eg/article_320067.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=320067

Order

320,067

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association of Serum Interlukin-6 and Transforming Growth Factor Beta with Response to Antiviral Therapy for Chronic Hepatitis C Patients

Details

Type

Article

Created At

28 Dec 2024