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318433

Detection of Vancomycin Resistance among Hospital and Community-acquired Methicillin-resistant Staphylococcus aureus Isolates

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen, responsible for infections acquired in both nosocomial and community settings. The first line of defense against life-threatening MRSA infections is vancomycin. The development of vancomycin resistance and a possible failure of MRSA treatment is associated with elevated vancomycin MICs. Objectives: The aim of the study was to detect the antibiotic sensitivity pattern of methicillin-resistant S. aureus and the prevalence of vancomycin resistance among these isolates. Methodology: Fifty-one MRSA isolates were studied. Identification and antimicrobial susceptibility profiles of MRSA isolates were determined by Vitek 2. Results: Community-acquired MRSA (CA-MRSA) strains were isolated from abscesses in soft tissues and skin (76%), while Hospital-acquired MRSA (HA-MRSA) strains were isolated mainly from pus obtained from surgical site infections and diabetic foot (57.7%), We detected 4 VISA/VRSA isolates out of 51 MRSA strains with a prevalence rate of 7.8%. Generally, CA-MRSA isolates were more susceptible to antibiotics than HA-MRSA isolates, except for ciprofloxacin. Conclusion: The study revealed the emergence of VISA/VRSA strains in isolated MRSA that were equally distributed between non-hospitalized and hospitalized patients being more common in young patients suffering from soft tissue and skin infections. All VRSA/VISA isolates were susceptible to tigecycline and linezolid.

DOI

10.21608/ejmm.2023.318433

Keywords

Methicillin-resistant Staphylococcus aureus, Vancomycin resistance

Authors

First Name

Noha

Last Name

Gohar

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nohagohar@yahoo.com

City

-

Orcid

-

First Name

Mariam

Last Name

Balah

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

dr.mariam_balah@cu.edu.eg

City

-

Orcid

-

First Name

Nahla

Last Name

Sahloul

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nahla.sahloul@kasralainy.edu.eg

City

-

Orcid

-

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-09-23

Publish Date

2023-10-01

Page Start

45

Page End

52

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 45-52.pdf

PDF . 461.4kB

Link

https://ejmm.journals.ekb.eg/article_318433.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=318433

Order

318,433

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Detection of Vancomycin Resistance among Hospital and Community-acquired Methicillin-resistant Staphylococcus aureus Isolates

Details

Type

Article

Created At

28 Dec 2024