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312061

Association between Dysbiosis of Key Species of Nasal Microbiome and Allergic Rhinitis in Adult Patients

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Nasal cavity of healthy adults is dominated by nasal microbiome as Corynebacterium on the genus level. The interactions between the local microbiota and the human immune system have a significant impact on the frequency of allergic diseases. Each year, there are more cases of inflammatory nasal mucosal diseases including allergic rhinitis (AR). Many of these illnesses still have an unclear cause. Since nasal microbiota have been found to play important role in regulating immune function, dysbiosis of the nasal microbiota may be the cause of AR. Objective: Investigate association between dysbiosis of nasal microbiome (Corynebacterium genus) and AR in adult patients. Methodology: This case control study included 56 subjects (28 in case group and 28 in control group), all were subjected to skin prick test and nasal swab collection for identification and quantitation of Corynebacterium by cultivation and real time PCR. Results: There was a statistically significant lower Corynebacterium colony count and relative expression (RQ) of 16S rRNA gene in AR patients compared to control group. Corynebacterium RQ of 16S rRNA gene was better in assessment of AR severity (sensitivity of 80%, a specificity of 84.6% and 82% accuracy at cut off ≤0.187 fold change) than Corynebacterium colony count (sensitivity of 73.3%, a specificity of 62.5% and 70% accuracy at a cut off value of ≤19.5×103 CFU/ml). Conclusion: Patients with decreased Corynebacterium colony count and RQ of 16S rRNA gene have a higher risk for AR.

DOI

10.21608/ejmm.2023.312061

Keywords

Allergic Rhinitis, Nasal microbiome, Dysbiosis, Corynebacterium

Authors

First Name

Alaa

Last Name

Rashad

MiddleName

E. M.

Affiliation

Medical Microbiology & Immunology Department, Allergy and Immunology Unit, Faculty of Medicine, Zagazig University, Egypt

Email

alaaemad121415@gmail.com

City

-

Orcid

-

First Name

Manal

Last Name

Bahgat

MiddleName

A.M.

Affiliation

Medical Microbiology & Immunology Department, Allergy and Immunology Unit, Faculty of Medicine, Zagazig University, Egypt

Email

manal.bahgat@gmail.com

City

-

Orcid

-

First Name

Nissreen

Last Name

Elbadawy

MiddleName

E.

Affiliation

Medical Microbiology & Immunology Department, Allergy and Immunology Unit, Faculty of Medicine, Zagazig University, Egypt

Email

nissreenbadawy77@gmail.com

City

Zagazig

Orcid

-

First Name

Ahmed

Last Name

El Sayed

MiddleName

I.

Affiliation

Otorhinolaryngology Department, Faculty of Medicine, Zagazig University, Egypt

Email

ahmed_mligy2007@yahoo.com

City

-

Orcid

-

First Name

Hanaa

Last Name

Abd El-Hady

MiddleName

I.

Affiliation

Medical Microbiology & Immunology Department, Allergy and Immunology Unit, Faculty of Medicine, Zagazig University, Egypt

Email

hanaaebrahim.he@gmail.com

City

-

Orcid

0000-0002-9934-4588

Volume

32

Article Issue

4

Related Issue

42768

Issue Date

2023-10-01

Receive Date

2023-08-10

Publish Date

2023-10-01

Page Start

9

Page End

16

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 4_Pages 9-16.pdf

PDF . 535.1kB

Link

https://ejmm.journals.ekb.eg/article_312061.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=312061

Order

312,061

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association between Dysbiosis of Key Species of Nasal Microbiome and Allergic Rhinitis in Adult Patients

Details

Type

Article

Created At

28 Dec 2024