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312957

The Impact of Staphylococcus aureus on Biofilm, Antibiotic Resistance and Cytotoxicity of Pseudomonas aeruginosa Isolated from Mixed Wound Infections

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pathogenicity and virulence

Abstract

Background: Pseudomonas aeruginosa and Staphylococcus aureus coexist in wounds causing severe illness. Objectives: This research was conducted to study the impact of S. aureus extract on P. aeruginosa. Methodology: Cell free extracts of four strains of S. aureus isolated from wounds were used to estimate their effect on biofilm formation, antibiotic resistance, and cytotoxicity of three clinical P. aeruginosa isolates from mixed wound infections. Results: Results disclosed that extracts of S. aureus significantly decreased biofilm formation and cytotoxicity in the tested P. aeruginosa isolates. Antibiotic resistance was assessed using three antibiotics; gentamicin, amikacin and imipenem. This is due to their higher resistance rates. Cell free extracts of S. aureus reduced antibiotic resistance of the tested P. aeruginosa isolates to aminoglycosides (Gentamicin and Amikacin) by (2-3) folds, while imipenem resistance was not changed.Conclusion: Based on this work's findings, S. aureus could affect P. aeruginosa in mixed wound infections through reduction of biofilm formation, cell cytotoxicity and antibiotic susceptibility.

DOI

10.21608/ejmm.2023.312957

Keywords

wounds, Biofilm, cytotoxic effect, Antibiotic susceptibilit

Authors

First Name

Areej

Last Name

El-Mahdy

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

Email

areej@mans.edu.eg

City

-

Orcid

0000-0002-8809-5491

First Name

Yasmen

Last Name

Mahran

MiddleName

F.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Email

dr.yasmena@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

3

Related Issue

41216

Issue Date

2023-07-01

Receive Date

2023-08-15

Publish Date

2023-07-01

Page Start

127

Page End

132

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 3_Pages 127-132.pdf

PDF . 261.0kB

Link

https://ejmm.journals.ekb.eg/article_312957.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=312957

Order

312,957

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Impact of Staphylococcus aureus on Biofilm, Antibiotic Resistance and Cytotoxicity of Pseudomonas aeruginosa Isolated from Mixed Wound Infections

Details

Type

Article

Created At

28 Dec 2024