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282383

Clinical Association of Serum Interleukin-17 and Interleukin-6 in Systemic Lupus Erythematosus Patients

Article

Last updated: 28 Dec 2024

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Abstract

Background: Management of Systemic Lupus Erythematosus (SLE) would be greatly assisted by certain biomarkers that perfectly reflect changes in disease activity. Objectives: This study was conducted to evaluate the role of IL-17, IL-6 and their ratio in SLE as regard disease activity, central nervous system CNS and renal involvement. Methodology: A case control study including SLE patients were subjected to clinical examination, assessment of SLE disease activity index (SLEDAI) and laboratory investigations versus healthy controls, quantitative determination of serum IL-17A and IL-6 levels by ELISA. Results: Elevated serum IL-17A and IL-6 levels in SLE cases than control. Serum IL-6 level was higher in renal group, whereas, higher serum IL-17 was detected in neurologically affected patients. Conclusion: SLE patients had significantly upregulated IL-17 and IL-6 levels. SLEDAI was significantly positively correlated with IL-17/IL-6 ratio. Thus, IL-17/ IL-6 ratio may accurately characterize Th17-driven disease than serum IL-17 or IL-6 alone.

DOI

10.21608/ejmm.2019.282383

Keywords

Cytokines, Interleukin-17, Interleukin-6, Systemic lupus erythematosus

Authors

First Name

Salwa

Last Name

El-Sabbah

MiddleName

B.

Affiliation

Medical Microbiology and Immunology Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

First Name

Takwa

Last Name

Meawed

MiddleName

El-Sayed

Affiliation

Medical Microbiology and Immunology Department; Faculty of Medicine, Zagazig University

Email

takwa_farid@hotmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Anis

MiddleName

H.

Affiliation

Medical Microbiology and Immunology Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

El-Shafey

MiddleName

M.

Affiliation

Rheumatology and Rehabilitation Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

First Name

Sahar

Last Name

Abdel Galil

MiddleName

M.

Affiliation

Rheumatology and Rehabilitation Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

First Name

Mohamad

Last Name

Nasr

MiddleName

M.

Affiliation

Dermatology & Venereology Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

El-Mosely

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department; Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

-

Volume

28

Article Issue

1

Related Issue

39190

Issue Date

2019-01-01

Receive Date

2023-01-26

Publish Date

2019-01-01

Page Start

47

Page End

53

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 28_Issue 1_Pages 47-53.pdf

PDF . 343.1kB

Link

https://ejmm.journals.ekb.eg/article_282383.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=282383

Order

7

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Clinical Association of Serum Interleukin-17 and Interleukin-6 in Systemic Lupus Erythematosus Patients

Details

Type

Article

Created At

28 Dec 2024