First Name

Rania

Last Name

Ismail

MiddleName

I.H.

Affiliation

Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

City

Orcid

First Name

Hebatallah

Last Name

Shaaban

MiddleName

A.

Affiliation

Background: Neonatal sepsis (NS) promotes unbalanced production of oxidant and anti-oxidant substances, causing excess of free oxygen radicals which may lead to tissue damage. NS carries high risk of morbidity and mortality, thus identification of biomarker to optimize early diagnosis and therapeutic interventions is highly desirable. Objectives: to detect cord blood thiobarbituric acid reactive substance (TBARS) in preterm neonates with maternal risk factor for sepsis as predictors of early onset neonatal sepsis (EOS). Methodology: cord TBARS was measured in 80 preterm neonates with antenatal risk factors for EOS, and classified into two groups: sepsis (n=25) and no-sepsis (n=55). Results: TBARS was significantly higher in sepsis than no-sepsis groups 10.50 (6.5 – 20.5) vs 3.00 (2.2 - 3.8) nmol/ml, (p=0.000). TBARS was significantly higher in culture proven sepsis than negative culture patients. TBARS was significantly higher in died neonates than survivors. Conclusion: cord TBARS in preterm neonates with maternal risk factor for sepsis can be used as diagnostic and prognostic biomarker for EOS.

Email

heba_ali@med.asu.edu.eg

City

Orcid

First Name

Menat Allah

Last Name

Shaaban

MiddleName

A.

Affiliation

Clinical pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

City

Orcid

First Name

Ahmed

Last Name

Emam

MiddleName

M.

Affiliation

Armed forces Hospital, Alexandria, Egypt

Email

City

Orcid