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293577

Candidaemia in Neonatal Intensive Care Units (NICU) at Beni-Suef Governorate

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Neonatal sepsis is a cause of mortality among neonates. Fungal infections are important hospital-acquired pathogens in neonates and infants admitted to the neonatal intensive care unit (NICU). Most neonatal fungal infections are due to Candida species, particularly Candida albicans.  The sources of candidiasis in NICU are often endogenous following colonization with fungi. About 10% of these babies get colonized in the first week of life and up to 64% babies get colonized by 4 weeks of hospital stay. Objectives: To assess the frequency of fungal infections in neonates attending (NICU) in Beni-Suef Governorate. Also, to correlate their presence with different risk factors. Methodology: A total of 52 neonates admitted to NICU in Beni suef Governorate. Blood culture both aerobically and anaerobically were done. Subcultures on blood agar, chocolate agar, MacConkey's agar, Sabouraud dextrose agar and bile esculin azide agar daily for 7 days before reporting blood cultures as negative. Candida spp. on SDA was identified by standard laboratory methods such microscopic and Gram stain identification, chla-mydospore formation on cornmeal agar, and Germ tube test to differentiate Candida albicans from other Candida species. Results: fungal infections were significantly assosciated with maternal candidiasis (P=0.003), higher level of CRP (P=0.023) and  with respiratory distressand jaundiced cases (P = 0.001, 0,001) respectively. There were insignificant differences regarding type of antibiotics given to neonates and fluconazole use as a prophylaxis in NICUs. There was a higher resistance to fluconazole and high susceptibility to amphotericin B. Conclusion: Mechanical ventilation has been associated with an increased risk, so continuous good hygiene measures and possibly antifungal prophylaxis in selected high-risk neonates is needed. Candida spp. may be resistant to azoles.

DOI

10.21608/ejmm.2023.293577

Keywords

Candidaemia, NICU, antifungal drugs, Neonatal sepsis

Authors

First Name

Naglaa Abdelmoniem

Last Name

Radi

MiddleName

Abdel-Moniem

Affiliation

Medical Microbiology and Immunology department, Faculty of Medicine, Beni -Suef University, Egypt

Email

naglaaradi@yahoo.com

City

-

Orcid

-

First Name

Amnna

Last Name

Mabrook

MiddleName

Gouda

Affiliation

Pediatric department, Faculty of Medicine, Beni-Suef University, Egypt

Email

amnnagouda@yahoo.com

City

01123456980

Orcid

-

First Name

Mervat

Last Name

Tohamy

MiddleName

Abdel-Baseer

Affiliation

Pediatrics department, Faculty of Medicine, Assuit University, Egypt

Email

mervatabdelaziz@rocketmail.com

City

Beni-Suef

Orcid

-

First Name

Mervat

Last Name

Abdel-Aziz

MiddleName

Abdel-Baseer Tohamy

Affiliation

Medical Microbiology and Immunology department, Faculty of Medicine, Beni -Suef University, Egypt

Email

abdelazizmervat82@gmail.com

City

-

Orcid

-

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-04-02

Publish Date

2023-04-01

Page Start

95

Page End

102

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 95-102.pdf

PDF . 313.4kB

Link

https://ejmm.journals.ekb.eg/article_293577.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=293577

Order

293,577

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Candidaemia in Neonatal Intensive Care Units (NICU) at Beni-Suef Governorate

Details

Type

Article

Created At

28 Dec 2024