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291146

Random SARS-CoV-2 antibody screening in Egypt during the COVID-19 third wave

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Since its first hit in 2019, COVID-19 pandemic has caused devastating consequences all over the globe. Serological testing can assess the level of humoral immune response and can guide for appropriate health decisions. Objective: This work aimed to test performance agreement between rapid tests and ELISA in serological detection of COVID-19 antibodies among generally randomized Egyptian participants. Methodology: Total 238 randomized Egyptian participants were serologically screened for SARS-CoV-2 IgM and IgG using COVID-19 IgM/IgG Combo rapid test and NovaLisa SARS-CoV-2 IgM and IgG ELISA kit in the period from March 2021 to June 2021 (pandemic third wave). Result: COVID-19 antibodies showed seroprevalence rate of 47.47%, distributed among symptomatic and asymptomatic individuals by rates of 51% and 42.5%, respectively. IgM and IgG antibodies had rates of 8.8% and 35.6%, while rates of 10.9% and 28.2% by ELISA respectively. The agreement between ELISA and rapid test was none to slight for IgM (p = 0.35), while fair for IgG; (p < 0.001). Conclusion: COVID-19 antibodies were positive in nearly half of enrolled participants. Rapid test showed fair agreement for IgG, while none to slight agreement for IgM with ELISA, thus can not replace ELISA in serological testing.

DOI

10.21608/ejmm.2023.291146

Keywords

COVID-19 antibodies, Serological diagnosis, SARS-CoV-2

Authors

First Name

Maha

Last Name

Gaafar

MiddleName

Mohammed

Affiliation

1Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

gaafar.maha@yahoo.co.uk

City

Cairo

Orcid

-

First Name

Mariam

Last Name

balah

MiddleName

Mahmoud

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

dr.mariam_balah@yahoo.com

City

Cairo

Orcid

-

First Name

Hebatallah

Last Name

Kassem

MiddleName

-

Affiliation

Department of Clinical and Chemical pathology, Kasr-Alainy Center of Clinical Oncology and Nuclear Medicine, School of Medicine, Cairo University

Email

heba.kasem@hotmail.com

City

Cairo

Orcid

-

First Name

Hend

Last Name

Sabry

MiddleName

Aly

Affiliation

Department of Public Health & Community Medicine, Kasr Al-Ainy School of Medicine

Email

hendalysabry@yahoo.com

City

Cairo

Orcid

-

First Name

Reem

Last Name

ElMessiery

MiddleName

-

Affiliation

4Department of Internal Medicine, Faculty of Medicine, Cairo University, Egypt

Email

relmessiery@kasralainy.edu.eg

City

Cairo

Orcid

-

First Name

Noha

Last Name

Soliman

MiddleName

Salah

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

nsal18@yahoo.com

City

-

Orcid

-

Volume

32

Article Issue

2

Related Issue

38873

Issue Date

2023-04-01

Receive Date

2023-03-16

Publish Date

2023-04-01

Page Start

79

Page End

87

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 32_Issue 2_Pages 79-87.pdf

PDF . 401.1kB

Link

https://ejmm.journals.ekb.eg/article_291146.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=291146

Order

291,146

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Random SARS-CoV-2 antibody screening in Egypt during the COVID-19 third wave

Details

Type

Article

Created At

28 Dec 2024