Background: Oropharyngeal candidiasis is an alarming sign that may indicates a serious systemic
disorder, especially in immunocompromised individuals who face the drastic side effects of the in
market antifungal drugs. This increases the need for developing effective and safe natural
products. Objectives: to evaluate the in vitro activities of both Fenugreek and Ginger rhizome
extracts and to compare their effects with nystatin and fluconazole antifungals against Candida
species. As far as we know, this is the first study to compare between the anti-candida activity of
both extracts. Methodology: Different species of Candida were isolated from patients suffering
from oropharyngeal candidiasis. The antifungal effects of methanolic extracts of Fenugreek and
Ginger rhizome were tested using disc diffusion method. Each extract was added to both nystatin
and fluconazole discs to measure the presence of synergistic effects. Results: Highly significant
synergism was detected between both extracts and fluconazole. Ginger rhizome extract was more
potent than Fenugreek extract. Conclusion: When used in combination with fluconazole,
Fenugreek and Ginger rhizome extracts are promising, safe and effective anti-Candida agents.