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305119

Spectrophotometric Assay of Cefadroxil via Oxidation and Bleaching Color of Leishman Dye

Article

Last updated: 28 Dec 2024

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Abstract

Abstract: A simple and sensitive spectrophotometric method has been developed for the estimate of cefadroxil in the pure form and in the dosage form(capsule). The suggested method involves the oxidation of cefadroxil with a known excess amount of N-bromosuccinimide (NBS) in an acidic medium (hydrochloric acid, 1M). The residual amount of oxidant (NBS) is determined by decolorization of the Leishman color dye. The absorbance of excess الفu dye was measured at 651 nm. The method follows Beer's law in the concentration range of 0.5-7.0 µg/ml. The linearity with determination coefficient 0.9941, molar absorptivity 3.5813 x 104 L.mol-1.cm-1 and Sandellʹs sensitivity index value 0.0106 µg/cm2. The LOD and LOQ values were 0.004 μg/ml and 0.015 μg/ml respectively. The relative standard deviation value was not more than 4.88% and the relative error was from -2.0 to 1.3%.  The method was applied successfully to the pharmaceutical preparations as a capsule.

DOI

10.18576//jpac.2023.305119

Keywords

Keywords : Leishman dye, Cefadroxil, N-Bromosuccinimide, Spectrophotometry

Authors

First Name

nabeel

Last Name

Othman

MiddleName

sabeeh

Affiliation

Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Email

nsn20002004@uomosul.edu.iq

City

-

Orcid

-

First Name

Amina

Last Name

D. Sulaman

MiddleName

-

Affiliation

Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Email

-

City

Mosul

Orcid

-

Volume

9

Article Issue

3

Related Issue

42090

Issue Date

2023-09-01

Receive Date

2023-05-10

Publish Date

2023-09-01

Page Start

7

Page End

12

Online ISSN

2357-0210

Link

https://jpac.journals.ekb.eg/article_305119.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=305119

Order

305,119

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Spectrophotometric Assay of Cefadroxil via Oxidation and Bleaching Color of Leishman Dye

Details

Type

Article

Created At

28 Dec 2024