297720

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Article

Last updated: 05 Jan 2025

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Abstract

Abstract: The estimation  of triflouperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an, oxidation-reduction reaction with 4,7diphenyi 1,10phenanthroline in the presence and  Iron(II) ammonium sulfate in the present   Cerric Sulfite  to produce a red-violet colored product with a maximum absorbance of 533nm.. The a molar absorptivity of 0.700x104 L.mole -1.cm-1, Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine triflouperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been established. Based on its, an oxidation-reduction reaction with 4-7 diphenyl 1,10phenanthroline  and iron(II) ammonium sulfate in the present ceric sulfite  as  the oxidizing agent serric sulphatr  , in aqueous solution The proposed method  has been effectively applied to pharmaceutical tablets.

DOI

10.21608/jpac.2023.297720

Keywords

Keywords: Trifluoperazine hydrochloride, 4, 7diphenyl 1, 10phenanthroline, Spectrophotometry, ceric sulfite

Authors

First Name

Ali

Last Name

Hussein

MiddleName

-

Affiliation

College of Science University of Mosul, Mosul, Iraq

Email

alialnimi542@gmail.com

City

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Orcid

0000-0003-4210-4783

First Name

S.Othman

Last Name

Nabbel

MiddleName

-

Affiliation

Department of Chemistry / College of Science University of Mosul, Mosul, Iraq

Email

nsn20002004@uomosul.edu.iq

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

41129

Issue Date

2023-05-01

Receive Date

2023-01-10

Publish Date

2023-05-01

Page Start

1

Page End

6

Online ISSN

2357-0210

Link

https://jpac.journals.ekb.eg/article_297720.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=297720

Order

297,720

Type

Original Article

Type Code

2,018

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Details

Type

Article

Created At

28 Dec 2024